Actively Recruiting
Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome
Led by University of Rochester · Updated on 2026-05-06
60
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome. Participants will complete a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. In addition, parents or caregivers will complete questionnaires and an interview about the participant's symptoms, communication abilities, daily functioning and overall health. The information collected from this study may help researchers better understand brain activity patterns and clinical features associated with Rett syndrome and support future research efforts.
CONDITIONS
Official Title
Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of classic Rett syndrome
- Confirmed pathogenic MECP2 genetic variant
- Past the clinical regression stage
- Age 2 years or older
- Able to tolerate noninvasive EEG recording
- Parent or caregiver willing and able to provide permission and complete questionnaires and interviews
- Neurologically healthy individuals age 2 years or older (controls)
- Able to tolerate noninvasive EEG recording (controls)
You will not qualify if you...
- Hearing impairment or hearing loss
- Medical conditions preventing safe EEG participation
- Inability to tolerate EEG procedures
- Any condition interfering with study participation or data quality as judged by the investigator
- History of genetic, neurological, or psychiatric disorders (controls)
- History of special education services (controls)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center
Rochester, New York, United States, 14620
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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