Effect of Daily Avocado Consumption on Cellular Aging in Female Breast Cancer Survivors: The ACCA Study

What this Trial Is About

Researchers are studying women who have survived breast cancer to understand how eating one avocado daily might affect biological aging, measured by the length of telomeres. The study focuses on breast cancer survivors aged 40 to 65, exploring whether dietary changes can influence aging markers and other health indicators such as inflammation, oxidative stress, cardiovascular markers, mental health symptoms, quality of life, and diet quality. This is a randomized controlled trial aiming to compare avocado consumption to a habitual diet with low avocado intake. Participants will be randomly assigned to one of two groups: an intervention group that will consume one avocado daily for four months alongside their usual diet, and a control group that will continue their usual diet without encouragement to eat avocados. Avocados will be provided free of charge to the intervention group every two weeks, supported by recipe leaflets to help incorporate avocados into their meals. The control group will maintain their regular diet without specific dietary changes. During the study, participants will complete questionnaires, provide blood and urine samples, and undergo measurements like blood pressure and body size assessments at the start and end of the four-month period. Researchers will evaluate changes in telomere length as the primary outcome, alongside secondary measures including telomerase activity, inflammation, oxidative stress, cardiovascular markers, mental health symptoms, quality of life, and diet. The study aims to understand the potential impact of avocado intake on cellular aging and overall health in breast cancer survivors.

Avocado Consumption and Cellular Aging in Breast Cancer Survivors