Studying Genetic and Biological Differences in Coeliac Disease and Dermatitis Herpetiformis to Improve Personalized Care

What this Trial Is About

Researchers are investigating the genetic, serological, immunological, and microbiota differences among various coeliac disease types, aiming to identify useful markers that predict outcomes for specific disease forms. The study also includes patients with dermatitis herpetiformis and healthy individuals to better understand the diverse clinical presentations and to support the development of personalized follow-up guidelines. Participants include adults previously diagnosed with coeliac disease or dermatitis herpetiformis, as well as healthy controls including friends or non-related family members of patients and additional biobank donors. The study will compare genetic predisposition, clinical features, immune responses, microbiota, and new biomedical markers across these groups to evaluate their prognostic value. During the study, participants will undergo assessments at baseline to measure genetic variants, serum transglutaminase antibodies, microbiota composition, quality of life, gastrointestinal symptoms, and diet adherence. This observational study involves no interventions and aims to collect data that may improve individualized care. Participation involves a one-time baseline evaluation with no specified follow-up visits, and recruitment is open to adults aged 18 and older.

Background of Different Phenotypes of Coeliac Disease