Understanding Basal Cell Role in Chronic Rhinosinusitis with Nasal Polyps and Allergic Rhinitis Using Patient and Healthy Control Samples

What this Trial Is About

Researchers are studying chronic rhinosinusitis with nasal polyps CRSwNP and allergic rhinitis by examining differences in basal and epithelial cells from patient and healthy control samples. They aim to understand cell functions, gene expression, and immune cell interactions that may contribute to these conditions. The study also includes an allergic rhinitis subset to explore whether changes are specific to CRSwNP or common in type 2 inflammatory diseases of the upper airways. The study collects tissue samples through surgical procedures such as conchotomy, aesthetic nose surgery, or functional endoscopic sinus surgery. These samples will be analyzed in the laboratory to investigate basal cell activation, genetic imprinting, secreted proteins, and interactions with regulatory T cells. Different sequencing techniques and co-culture experiments will be used to compare cells from CRSwNP patients, allergic rhinitis patients, and healthy controls. Participants will provide tissue samples during surgery, and researchers will perform functional assays, gene expression profiling, and co-culture studies over 9 to 24 months. The study will measure functional differences between cell types, gene expression patterns, and immune cell interactions. The goal is to better understand the underlying mechanisms of CRSwNP and related conditions to inform future research. Participation involves sample collection during surgery and follow-up laboratory analysis without ongoing treatment or intervention.

Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps