Actively Recruiting
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-03-22
300
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
U
Universitaire Ziekenhuizen KU Leuven
Lead Sponsor
R
Regeneron Pharmaceuticals
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying chronic rhinosinusitis with nasal polyps (CRSwNP) and allergic rhinitis by examining differences in basal and epithelial cells from patient and healthy control samples. They aim to understand cell functions, gene expression, and immune cell interactions that may contribute to these conditions. The study also includes an allergic rhinitis subset to explore whether changes are specific to CRSwNP or common in type 2 inflammatory diseases of the upper airways. The study collects tissue samples through surgical procedures such as conchotomy, aesthetic nose surgery, or functional endoscopic sinus surgery. These samples will be analyzed in the laboratory to investigate basal cell activation, genetic imprinting, secreted proteins, and interactions with regulatory T cells. Different sequencing techniques and co-culture experiments will be used to compare cells from CRSwNP patients, allergic rhinitis patients, and healthy controls. Participants will provide tissue samples during surgery, and researchers will perform functional assays, gene expression profiling, and co-culture studies over 9 to 24 months. The study will measure functional differences between cell types, gene expression patterns, and immune cell interactions. The goal is to better understand the underlying mechanisms of CRSwNP and related conditions to inform future research. Participation involves sample collection during surgery and follow-up laboratory analysis without ongoing treatment or intervention.
CONDITIONS
Brief Title
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over the age of 18
- Males and females
You will not qualify if you...
- Chronic rhinosinusitis with nasal polyps (CRSwNP)
- Allergic rhinitis (AR)
- Current smoker or less than 1-year ex-smoker
- Underlying systemic diseases such as Morbus Wegener or Churg Strauss Syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo procedures such as conchotomy, aesthetic nose surgery, or functional endoscopic sinus operation to obtain tissue samples for study.
1 visit (in-person)
Duration - 9 to 24 months
Participants' samples are studied over time to investigate cellular functions, gene expression, and cell interactions related to chronic rhinosinusitis with nasal polyps and allergic rhinitis.
No additional visits required for participants
Trial Site Locations
Total: 1 location
1
Peter Hellings
Leuven, Belgium, 3000
Actively Recruiting
Research Team
P
Peter Hellings, MD, PhD
D
Dominique Bullens, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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