Actively Recruiting
Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Led by State University of New York at Buffalo · Updated on 2025-08-22
50
Participants Needed
3
Research Sites
229 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.
CONDITIONS
Official Title
Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 65 to 85 years
- Poor sleep quality with a Pittsburgh Sleep Quality Index (PSQI) global score greater than 5
You will not qualify if you...
- Dementia indicated by a Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score less than 20
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
State University of New York at Buffalo
Buffalo, New York, United States, 14203
Not Yet Recruiting
2
University at Buffalo State University of New York
Buffalo, New York, United States, 14203
Not Yet Recruiting
3
Buffalo Veteran Affairs Medical Center
Buffalo, New York, United States, 14215
Actively Recruiting
Research Team
C
Carleara Weiss, PhD, MS, RN
CONTACT
R
Rebecca A Lorenz, PhD, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here