NAD+‒circadian rhythm coupling in dementia.
Shi-Qi Zhang, Jiyeon Lee, Jun-Ping Pan...
https://pubmed.ncbi.nlm.nih.gov/42063312Actively Recruiting
Phase Not Applicable
Age: 65Years - 85Years
All Genders
Healthy Volunteers
ID05500170
The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans
Led by State University of New York at Buffalo · Updated on 2025-08-22
50
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Poor sleep quality and short sleep duration are linked to cognitive impairment in older adults, often involving a decrease in brain-derived neurotrophic factor (BDNF). This research evaluates the effects of nicotinamide riboside (NR), a vitamin B3 form that increases NAD+ levels, on sleep and cognitive function in older adults. The study also explores how NR impacts serum BDNF, which may serve as a biomarker related to sleep quality. Participants will be randomly assigned to receive either 500 mg of NR twice daily or a placebo containing micro cellulose powder twice daily. The study lasts 12 weeks, during which the effects of NR supplementation on sleep quality and cognitive function will be assessed. Researchers will compare changes from the baseline to the endpoint in both sleep and cognition measures. Throughout the study, participants will undergo comprehensive sleep and cognitive evaluations using subjective and objective tools. Sleep quality will be assessed using the Pittsburgh Sleep Quality Index, while cognitive function changes will also be measured. The study includes continuous monitoring of serum BDNF levels to examine its association with sleep improvements. Overall participation lasts 12 weeks with follow-up assessments at the end of this period.
CONDITIONS
Brief Title
Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Who Can Participate
Age: 65Years - 85Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Adults aged 65 to 85 years
- Pittsburgh Sleep Quality Index (PSQI) global score greater than 5 indicating poor sleep quality
You will not qualify if you...
- Dementia indicated by Veteran Affairs - St. Louis University Mental Status (VA-SLUMS) score less than 20
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 12 weeks
Participants receive either nicotinamide riboside or placebo twice daily to assess effects on sleep quality and cognition.
Weekly visits for up to 12 weeks
Trial Site Locations
Total: 3 locations
1
State University of New York at Buffalo
Buffalo, New York, United States, 14203
Not Yet Recruiting
2
University at Buffalo State University of New York
Buffalo, New York, United States, 14203
Not Yet Recruiting
3
Buffalo Veteran Affairs Medical Center
Buffalo, New York, United States, 14215
Actively Recruiting
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Research Team
C
Carleara Weiss, PhD, MS, RN
R
Rebecca A Lorenz, PhD, RN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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