Actively Recruiting
Benefits of a Renal Rehabilitation Program Adapted to Uremic Patients on Daily Hemodialysis at Low Dialysate Flow Rate
Led by Brugmann University Hospital · Updated on 2026-02-17
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a renal rehabilitation program tailored for patients with terminal chronic kidney disease (CKD) who require hemodialysis. The study focuses on patients recently hospitalized due to acute medical events. It aims to explore the benefits of daily low dialysate flow rate hemodialysis (LDF), a newer dialysis method, in combination with rehabilitation, to address common issues like sarcopenia and decreased physical function associated with CKD and conventional hemodialysis. The study involves patients undergoing low flow rate hemodialysis five times per week along with a customized multidisciplinary rehabilitation program. This approach is compared to conventional hemodialysis, aiming to maintain dialysis efficiency while allowing better cardiovascular tolerance and physical recovery. The rehabilitation program and dialysis treatments are integrated during the patient's stay in a rehabilitation ward, which can last up to 24 weeks. Participants will be assessed through various tests at admission and discharge from the rehabilitation ward, including hand grip strength, physical performance, walking ability, muscle ultrasound, and quality of life surveys. Blood tests measuring myostatin, activin A, and IGF1 levels will also be conducted. The study monitors dialysis adequacy and the patient's response to the rehabilitation program, tracking progress over the rehabilitation period to evaluate improvements in muscle strength and overall physical condition.
CONDITIONS
Brief Title
Benefits of a Renal Rehabilitation Program Adapted to Uremic Patients on Daily Hemodialysis at Low Dialysate Flow Rate.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient with terminal chronic kidney disease requiring hemodialysis treatment
- Patient recently hospitalized for an acute medical event
You will not qualify if you...
- Dementia or mild cognitive impairment with MMSE score below 20/30
- Decompensated psychiatric disorder or behavioral issues
- Pregnant woman
- Recovery of kidney function allowing stopping hemodialysis
- Candidate for neurological rehabilitation
- Recent spinal cord injury
- Absolute or relative contraindication to stress test
- Severe or poorly tolerated cardiac rhythm disorder
- Severe or symptomatic obstruction to left ventricular ejection
- Decompensated heart failure
- Acute myocarditis, pericarditis, or endocarditis
- Acute aortic dissection
- High-risk emboligenic intracardiac thrombus
- Significant stenosis of the common trunk
- Ventricular aneurysm
- Supraventricular tachycardia with poorly controlled ventricular rate, acquired high-degree or complete block
- Obstructive cardiomyopathy with high resting gradient
- Recent stroke or transient ischemic attack
- Acute venous thrombosis with or without pulmonary embolism
- Poorly controlled clinical condition such as severe anemia, significant electrolyte imbalance, or hyperthyroidism
- Lack of cooperation from the patient
- Blood pressure above 200/110 mmHg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 24 weeks
Participants receive low flow rate hemodialysis five times per week along with a tailor made multidisciplinary rehabilitation program.
Regular visits during rehabilitation program
Trial Site Locations
Total: 1 location
1
CHU Brugmann
Brussels, Belgium, 1020
Actively Recruiting
Research Team
J
Joris Vanparys, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here