Study of a Renal Rehabilitation Program Using Daily Low Flow Rate Hemodialysis in Patients with End-Stage Chronic Kidney Disease After Acute Illness

What this Trial Is About

Researchers are evaluating a renal rehabilitation program tailored for patients with terminal chronic kidney disease CKD who require hemodialysis. The study focuses on patients recently hospitalized due to acute medical events. It aims to explore the benefits of daily low dialysate flow rate hemodialysis LDF, a newer dialysis method, in combination with rehabilitation, to address common issues like sarcopenia and decreased physical function associated with CKD and conventional hemodialysis. The study involves patients undergoing low flow rate hemodialysis five times per week along with a customized multidisciplinary rehabilitation program. This approach is compared to conventional hemodialysis, aiming to maintain dialysis efficiency while allowing better cardiovascular tolerance and physical recovery. The rehabilitation program and dialysis treatments are integrated during the patients stay in a rehabilitation ward, which can last up to 24 weeks. Participants will be assessed through various tests at admission and discharge from the rehabilitation ward, including hand grip strength, physical performance, walking ability, muscle ultrasound, and quality of life surveys. Blood tests measuring myostatin, activin A, and IGF1 levels will also be conducted. The study monitors dialysis adequacy and the patients response to the rehabilitation program, tracking progress over the rehabilitation period to evaluate improvements in muscle strength and overall physical condition.

Benefits of a Renal Rehabilitation Program Adapted to Uremic Patients on Daily Hemodialysis at Low Dialysate Flow Rate.