Impact of Natural Insulin Secretion on Health Outcomes and Optimizing C-peptide Testing in Adults with Insulin-Treated Diabetes

What This Trial Is About

Researchers are studying the effects of retaining natural insulin production, measured by C-peptide levels, on quality of life and clinical outcomes in adults with insulin-treated diabetes, including type 1 diabetes. The study aims to identify the most practical and accurate ways to measure insulin secretion and how these measures relate to patient benefits and glucose control over time. The research has two parts. The first involves following 500 adults with insulin-treated diabetes from a previous large study, assessing their insulin secretion and related health measures yearly for up to nine years after diagnosis. The second part recruits 200 adults with type 1 diabetes, who will undergo detailed insulin secretion testing both in a research setting and at home using finger-prick tests after meals, along with continuous glucose monitoring for two weeks. Participants will provide blood samples and complete questionnaires on quality of life and emotional burden. Researchers will analyze glucose variability and hypoglycemia using continuous glucose monitors, and compare home testing to clinic results. This study will help design future trials for treatments aimed at preserving or restoring insulin secretion and better understand the long-term benefits of these approaches.

Benefits of Retained Insulin for Good Health