Actively Recruiting
A Pilot Study to Evaluate Equol and Its Effects on Menopausal Symptoms Experienced by Women in Singapore
Led by Ang Seng Bin · Updated on 2025-08-22
300
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
A
Ang Seng Bin
Lead Sponsor
O
Otsuka Pharmaceutical Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main aim of this study is to evaluate the effect of equol on menopausal symptoms of women. Our hypothesis is that equol producers will have milder menopausal symptoms compared to non-equol producers. Equol is known as a metabolite produced by gut microbiota from soy-related diet and has estrogen-like activity compared to the isoflavones from soybean. Previous studies have shown that some women can produce equol from soy-related diet, but the others cannot because they don't have the bacteria which can metabolite daidzein in gut even if they take isoflavones thorough soybean products. This study will involve participants consuming a soy protein bar and collection of urine samples before and after its consumption.
CONDITIONS
Official Title
A Pilot Study to Evaluate Equol and Its Effects on Menopausal Symptoms Experienced by Women in Singapore
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 40-60
You will not qualify if you...
- Pregnant women
- Allergy to Soy
- Allergy to nuts
- Consumed antibiotics within 7 days of the study
- Has a history of autoimmune diseases
- Has a history of thyroid disease
- On medical treatment with hormone therapy, elective oestrogen receptors modulators
- Consuming equol-containing supplements or food
- Consuming painkillers
- Consuming anti-depressants and/or sleeping pills
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
KK Women's and Children's Hospital
Singapore, Singapore
Actively Recruiting
Research Team
S
Seng Bin Dr Ang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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