Prevalence of the equol-producer phenotype and its relationship with dietary isoflavone and serum lipids in healthy Chinese adults.
Baohua Liu, Liqiang Qin, Aiping Liu...
https://pubmed.ncbi.nlm.nih.gov/20671375Actively Recruiting
Age: 40Years - 60Years
FEMALE
Healthy Volunteers
ID07136220
A Pilot Study to Evaluate Equol and Its Effects on Menopausal Symptoms Experienced by Women in Singapore
Led by Ang Seng Bin · Updated on 2025-08-22
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
A
Ang Seng Bin
Lead Sponsor
O
Otsuka Pharmaceutical Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate the effect of equol, a compound produced by gut bacteria from soy-related diets, on menopausal symptoms in women aged 40 to 60. The study hypothesizes that women who produce equol may experience milder menopausal symptoms compared to those who do not. Equol has estrogen-like activity, which is thought to influence these symptoms. Participants will consume a soy protein bar after dinner on the first day of the study. Urine samples will be collected before and after consuming the soy bar to measure equol concentration. The samples will be analyzed to assess the relationship between equol production and menopausal symptoms. During the study, participants will have their height, weight, and blood pressure measured and will complete questionnaires about their demographics, menopausal symptoms, diet, and physical activity. Urine samples will be collected on two consecutive mornings and sent for analysis. The main outcome measured is the urine equol concentration before and after soy bar consumption, helping researchers understand equol's role in menopausal symptoms.
CONDITIONS
Brief Title
A Pilot Study to Evaluate Equol and Its Effects on Menopausal Symptoms Experienced by Women in Singapore
Who Can Participate
Age: 40Years - 60Years
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Women aged 40-60
You will not qualify if you...
- Pregnant women
- Allergy to Soy
- Allergy to nuts
- Consumed antibiotics within 7 days of the study
- Has a history of autoimmune diseases
- Has a history of thyroid disease
- On medical treatment with hormone therapy, elective oestrogen receptors modulators
- Consuming equol-containing supplements or food
- Consuming painkillers
- Consuming anti-depressants and/or sleeping pills
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 2 days
Participants provide baseline information and samples including height, weight, blood pressure, and questionnaires about menopausal symptoms and lifestyle. First morning urine sample is collected before consuming a soy protein bar.
2 visits (in-person and sample collection)
Monitoring
Duration - 2 days
Participants consume a soy protein bar after dinner on Day 1 and collect a second first morning urine sample the next day for analysis of urinary equol concentration.
1 visit (in-person) and 2 urine sample collections
Trial Site Locations
Total: 1 location
1
KK Women's and Children's Hospital
Singapore, Singapore
Actively Recruiting
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Research Team
S
Seng Bin Dr Ang
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Equol-producing status, isoflavone intake, and breast density in a sample of U.S. Chinese women.
Marilyn Tseng, Celia Byrne, Mindy S Kurzer...
https://pubmed.ncbi.nlm.nih.gov/24019393