Bleeding of Unknown Cause, Insight Into a Multifactorial Bleeding Disorder: a Swiss Case-control Study

What this Trial Is About

This research aims to identify specific biological patterns in patients who experience bleeding of unknown cause and to study the underlying mechanisms for each patient group. It is a prospective cohort study comparing these patients to a control group of healthy individuals without bleeding tendencies. The study is being conducted by the University Hospital in Geneva and spans over several years to gain insight into this complex bleeding disorder. Participants include patients with unexplained bleeding and healthy volunteers as controls. At the start, blood samples are taken from all participants to evaluate various aspects of blood clotting, such as fibrin clot polymerization, permeability, fibrinolysis, thrombin generation, and platelet coating. These diagnostic tests help researchers analyze the differences between patients and controls. The study follows participants for three years to observe bleeding episodes and other health outcomes. During the study, participants will undergo several assessments including blood tests, quality of life questionnaires, and bleeding evaluations using recognized tools like the ISTH bleeding assessment tool. Researchers will monitor major and non-major bleeding episodes over three years. The study also collects detailed laboratory data at inclusion, such as fibrinogen levels and clot structure imaging. This comprehensive follow-up helps researchers understand the natural course and impact of bleeding disorders over time.

Bleeding of Unknown Cause: a Swiss Case-control Study