Study of Alzheimers Disease Biomarkers in Tear Fluid and Dry Blood Spots in Adults Undergoing Lumbar Puncture

What this Trial Is About

Researchers are investigating whether Alzheimers disease biomarkers can be detected in tear fluid and dried blood spots from patients with Alzheimers disease, other dementia types, and control participants without neurological disease. This observational study focuses on people undergoing evaluation for neurodegenerative diseases at a memory clinic, aiming to compare biological markers across these groups to improve understanding of Alzheimers and related dementias. On the day participants have a lumbar puncture as part of their clinical evaluation, samples of tear fluid and dried blood spots will be collected. Tear fluid is gathered using Shirmers test, while dried blood spots are made from a small finger prick onto filter paper. A sub-study invites consenting participants to repeat the dried blood spot test at home one week later, submitting samples at their next clinic visit. These samples, along with blood and cerebrospinal fluid, will be examined for Alzheimers disease-related pathology. Participants will provide tear fluid, dried blood spots, blood, and cerebrospinal fluid samples during their clinical visits. Researchers will analyze these samples to identify Alzheimers biomarkers over a two-year period. The study involves patients diagnosed with Alzheimers disease, other dementias, and control individuals without neurological disease. Safety and fitness for participation are assessed, and the total study duration depends on clinical schedules and sample collections.

Blood And Tears in Alzheimer's Disease