Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
Healthy Volunteers
ID05287750

Brain Diseases on 7.0T Magnetic Resonance Imaging

Led by Chinese PLA General Hospital · Updated on 2022-03-18

200

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the use of 7-Tesla (7T) and 3T magnetic resonance imaging (MRI) to detect brain diseases such as brain tumors and cerebrovascular diseases. The study aims to compare the increased sensitivity and accuracy of 7T MRI with the standard 3T MRI, focusing on improved lesion detection and diagnostic confidence that may help guide treatment decisions. This interventional study is sponsored by the Chinese PLA General Hospital and involves adults aged 18 to 80 years with brain diseases who are clinically stable. Participants will receive MRI scans using both 7T and 3T devices. The study will assess image characteristics and diagnostic accuracy by comparing the MRI scans to biopsy results. The benefits of 7T MRI include better anatomic detail, higher spatial and spectral resolution, and shorter scan times compared to 3T MRI. The study involves diagnostic imaging procedures performed within one month after biopsy and follow-up assessments up to six months. During the study, researchers will evaluate how well the MRI scans correspond to actual brain tumor cells found in biopsies and examine the visibility of white matter tracts on both 7T and 3T MRI. They will also study the relationship between MRI findings and patients' functional status one month after surgery. Participants will undergo MRI scans and clinical assessments, with the main outcomes measured shortly after biopsy and at six months. The total participation duration varies depending on individual biopsy and follow-up schedules.

CONDITIONS

Brief Title

Brain Diseases on 7.0T Magnetic Resonance Imaging

Who Can Participate

Age: 18Years - 80Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 to 80 years
  • Diagnosed with brain diseases such as brain tumor or cerebrovascular diseases
  • No contraindications to MRI or intravenous contrast agent use
  • Clinically stable condition
Not Eligible

You will not qualify if you...

  • Under 18 or over 80 years old
  • Pregnant or have contraindications to MRI
  • Have not provided informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Within a month after biopsy

Participants receive 7T Magnetic Resonance Imaging to detect image characteristics and improve diagnostic accuracy of brain diseases.

1 visit (in-person)

Long-term Monitoring

Duration - Up to six months after biopsy

Participants are monitored for the visibility of white matter tracts and correlation of imaging findings with clinical status up to six months after biopsy.

1 follow-up visit

Trial Site Locations

Total: 1 location

1

Chinese PLA General Hospital

Beijing, China, 100853

Actively Recruiting

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Research Team

K

Kun Cheng, M.S.

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

0

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Published Research Related To This Trial

Synthesized 7T MPRAGE From 3T MPRAGE Using Generative Adversarial Network and Validation in Clinical Brain Imaging: A Feasibility Study.

Caohui Duan, Xiangbing Bian, Kun Cheng...

https://pubmed.ncbi.nlm.nih.gov/37559435