Imaging Parkinsons Disease Using 7-Tesla MRI to Identify Brain Changes and Track Symptoms Over Time

What this Trial Is About

Researchers are investigating the imaging characteristics of Parkinsons Disease PD using 7-Tesla 7T magnetic resonance imaging MRI. The study aims to detect subtle changes in patients with a short history of PD compared to healthy individuals, explore imaging differences among PD subtypes, and identify neuroimaging biomarkers that can distinguish these subtypes. This observational study also includes a long-term follow-up to assess the relationship between imaging changes and clinical symptom progression. Participants will undergo 7T-MRI scanning to capture detailed brain images. The study focuses on comparing imaging data from different PD subtypes and healthy subjects to understand functional and structural brain connectivity alterations. Follow-up imaging and clinical assessments will be conducted over several years to monitor changes and their correlation with motor symptoms. During the study, participants will have regular MRI scans and clinical evaluations to track motor symptoms and brain connectivity features. Researchers will measure changes in motor function five years after enrollment, alongside clinical and imaging variables. The study includes healthy volunteers and patients with PD, with ongoing observation to link imaging findings to disease progression and motor symptom changes.

7.0T Magnetic Resonance Imaging Study of Parkinson's Disease