Actively Recruiting
Brain Slice Explants to Predict Drug Response in Brain Tumors
Led by UNC Lineberger Comprehensive Cancer Center · Updated on 2025-08-29
50
Participants Needed
1
Research Sites
239 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This biospecimen collection study will evaluate the feasibility of engrafting and testing resected Central nervous system (CNS) tumors tumor tissue ex vivo to estimate drug response, in pediatric and adult subjects. CNS tumors display remarkable heterogeneity and unfortunately there are no reliable precision oncology platforms that can identify the most effective therapy for each patient. Recent work has demonstrated the success of functional precision oncology platforms using patient-derived explant (PDE) at predicting drug response in various cancers. Since PDEs maintain important aspects of tumor heterogeneity they may prove effective as functional models for CNS tumors. The purpose of this study is to explore the feasibility of using a novel PDE platform to generate drug sensitivity scores from patients with central nervous system tumors in Pediatric and adult subjects having low- or high-grade CNS tumors resected. The secondary objective is to estimate the proportion of successfully scaled PDEs generated per given tumor size.
CONDITIONS
Official Title
Brain Slice Explants to Predict Drug Response in Brain Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent obtained or parental/surrogate consent for pediatric subjects
- Diagnosed with a tumor in the central nervous system planned for surgical removal
- Willing and able to comply with study procedures as judged by the investigator
You will not qualify if you...
- Having any serious medical or psychiatric disorder interfering with informed consent
- Being currently incarcerated
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27516
Actively Recruiting
Research Team
D
Devin McCarthy
CONTACT
L
Luz Cuaboy
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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