Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells.
Prajwal Rajappa, William S Cobb, Emma Vartanian...
https://pubmed.ncbi.nlm.nih.gov/28039266Actively Recruiting
All Genders
Healthy Volunteers
ID04852354
Tissue Collection for Drug Screening and Bioanalysis of Central Nervous System Tumors
Led by Weill Medical College of Cornell University ยท Updated on 2025-12-17
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying central nervous system (CNS) tumors to gain a better understanding of their characteristics. This observational study collects tissue samples from patients with CNS tumors during surgery and post-mortem to develop tumor cell lines and models. The goal is to test how these tumors respond to various drugs, which may lead to new treatment options and identification of therapy targets. Samples collected include tumor tissue, blood, cerebrospinal fluid, saliva, skull, and dura from patients undergoing neurosurgery. Saliva samples are also collected from parents of pediatric tumor patients. In addition, blood and cerebrospinal fluid samples are taken from patients without tumors undergoing neurosurgery. Post-mortem donations include whole brain, spinal cord, biofluids, and skin biopsies from brain tumor patients. These samples support various analyses such as DNA/RNA sequencing, proteomics, immunoprofiling, and drug screening. Participants provide biological samples during their routine surgical procedures or through autopsy donation. Researchers analyze the genetic, immunohistochemical, cellular, and molecular profiles of the tumor samples over an average of 1 to 3 years. Additional samples from parents and non-tumor patients help with comparisons. This study involves no interventions but focuses on detailed tissue analysis to improve CNS tumor research and future therapies.
CONDITIONS
Brief Title
Tissue Collection for Drug Screening and Bioanalysis
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Subject has a suspected or confirmed neoplastic CNS lesion and is undergoing neurosurgery with tissue removal
- Tissue available beyond diagnostic needs during surgery
- Subjects of all ages, including neonates (0-4 weeks) and pregnant individuals, are included
- Non-tumor subjects between 4 weeks and 21 years undergoing neurosurgery without CNS tumor diagnosis
- Biological parents of patients enrolled in tumor neurosurgery cohort and not pregnant at enrollment
- Subjects diagnosed with neoplastic CNS lesions at time of passing for autopsy donation
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Tissue Collection During Neurosurgery
Duration - Occurs on the day of surgery
Participants undergoing routine neurosurgery provide tissue and biological samples such as tumor tissue, blood, cerebrospinal fluid, saliva, skull, and dura for research purposes if extra tissue is available.
1 surgical collection visit (in-person)
Autopsy Donation
Duration - Occurs post-mortem
Post-mortem biospecimens including whole brain, spinal cord, biofluids, and skin biopsy are collected from participants who donate tissue after passing.
1 collection visit (post-mortem)
Sample Analysis and Monitoring
Duration - Up to 3 years
Collected samples undergo various analyses such as DNA/RNA extraction, sequencing, methylome analyses, proteomic analysis, immunoprofiling, and primary culturing to support research.
Trial Site Locations
Total: 1 location
1
Weill Cornell Medicine
New York, New York, United States, 10021
Actively Recruiting
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Research Team
J
Jeffrey Greenfield, M.D.
P
Pediatric Neurosurgery
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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