Actively Recruiting
Breastmilk Composition in Response to a Bout of Exercise
Led by Mayo Clinic · Updated on 2025-05-16
60
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of postpartum maternal exercise on the composition of breastmilk and how these changes may benefit infant health. The study focuses on understanding how nutrients and antibodies in breastmilk, influenced by factors like maternal obesity and type 2 diabetes, contribute to infant growth, development, and immunity. This observational study aims to fill the knowledge gap about how exercise after childbirth affects breastmilk and infant health outcomes such as childhood obesity and diabetes. Participants are grouped based on their exercise habits: those who perform moderate-intensity exercise more than three days per week and those who exercise one day or less per week. The study observes natural variations in breastmilk composition related to these activity levels without assigning specific interventions. Pre-pregnancy body mass index (BMI) categories are also considered as part of the analysis. During the study, researchers will measure breastmilk exosome concentration one month after the exercise bout to assess changes in breastmilk composition. Participants will be monitored for health status and relevant medical conditions. The study includes women aged 18 to 45 years and excludes those with certain medical conditions or medication use that could interfere with study completion. The total participation duration and visit schedule are not specified.
CONDITIONS
Brief Title
Breastmilk in Response to a Bout of Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants aged 18 to 45 years
- Willingness to breastfeed and participate in study procedures
- Ability to be classified into exercise groups: more than 3 days per week or 1 day or less per week of moderate-intensity exercise
- Pre-pregnancy BMI between 18.5 and 39.99
You will not qualify if you...
- Active coronary artery disease or heart failure
- Participation in structured exercise exceeding group limits (\u2265 1 day/week for inactive group or < 3 days/week for active group)
- Medical conditions interfering with study completion, including abnormal liver or kidney function
- Unstable medication use for antihypertensive, thyroid, anti-depressant, or lipid-lowering drugs in past 2 months
- Uncontrolled thyroid disease
- Alcohol or recreational drug abuse
- Active tobacco smoking within past 3 months
- Active infections not expected to resolve before study procedures
- Uncontrolled high blood pressure
- Recent injury, muscular disorder, carcinogenic disease, or other significant medical disorder affecting study participation
- Active pregnancy
- Use of any other medication contraindicated for participation in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 month
Participants who meet eligibility criteria are monitored to assess breastmilk composition in response to their exercise habits.
Multiple sample collections during this period
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
L
Linda Szymanski, M.D., Ph.D.
M
Mark Pataky, Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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