Actively Recruiting
Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function
Led by Philippe Klee, MD-PhD · Updated on 2025-04-02
50
Participants Needed
1
Research Sites
214 weeks
Total Duration
On this page
Sponsors
P
Philippe Klee, MD-PhD
Lead Sponsor
U
University of Geneva, Switzerland
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism. The values will be compared to those obtained in healthy volunteers. The aim of the study is to test the validity of 1,5-anhydroglucitol as a novel biomarker of beta-cell mass and function in children with obesity with or without type 2 diabetes.
CONDITIONS
Official Title
Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 12 to 16 years
- Obesity defined as a body-mass index above the 97th percentile
- Ability to give informed consent as documented by signature
You will not qualify if you...
- Diabetes mellitus with positive autoantibodies against islets, insulin, islet antigen 2, glutamic acid decarboxylase, or Zinc transporter 8
- Known liver disease other than non-alcoholic fatty liver disease (NAFLD)
- Treatment with oral antidiabetic drugs, glucagon-like peptide-1 analogues, or insulin at the time of or less than 2 weeks before inclusion
- Treatment with drugs known to affect liver function
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital of Geneva
Geneva, Canton of Geneva, Switzerland, 1211
Actively Recruiting
Research Team
P
Philippe Klee
CONTACT
P
Pierre Maechler
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here