Actively Recruiting
Cannabis Abstinence and Neurocognitive Assessment in Adolescence
Led by University Hospital Pilsen · Updated on 2025-09-19
29
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to assess how cognitive functions develop after achieving abstinence in adolescents diagnosed with cannabis dependence or harmful cannabis use. The study focuses on a group of young people aged 15 to 18 years, with abstinence confirmed through toxicological testing. The goal is to understand changes in brain function following cannabis abstinence during adolescence. Participants undergo neurocognitive assessments using a variety of tests, including the Trail Making Test, Auditory Verbal Learning Test, Stroop Test, Tower of London, and Continuous Performance Test-Identical Pairs. Urine toxicological assessments are used to confirm abstinence. The study observes cognitive performance changes over an 8-week period. During the study, participants will take these cognitive tests and provide urine samples to monitor abstinence. Researchers will measure changes in cognitive abilities such as attention, memory, and problem-solving. The main outcome is the change in performance on the Trail Making Test Part B after 8 weeks. Safety and adherence to abstinence are closely monitored throughout the study period, which lasts 8 weeks.
CONDITIONS
Brief Title
Cannabis Abstinence and Neurocognitive Assessment in Adolescence
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adolescents aged 15-18 years with a diagnosis of cannabis dependence or harmful cannabis use.
You will not qualify if you...
- Psychiatric comorbidity such as psychotic disorders, mood disorders, severe organic brain damage, or autism spectrum disorder, except stabilized anxiety disorder.
- Use of antipsychotics prescribed for psychosis.
- Severe endocrine disorders including diabetes mellitus and thyroid dysfunction.
- Severe cardiovascular disease.
- Breaking abstinence between the first and second neuropsychological assessments.
- Severe mental state worsening requiring changes in psychopharmacological treatment.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants undergo neurocognitive testing and urine toxicological assessments to evaluate cognitive functions and confirm abstinence.
2 neurocognitive and toxicological assessment visits
Duration - Up to 8 weeks
Participants are observed to assess cognitive performance changes following cannabis abstinence.
Follow-up assessments may occur to monitor cognitive development
Trial Site Locations
Total: 1 location
1
University Hospital Pilsen
Pilsen, Czechia, Czechia, 30100
Actively Recruiting
Research Team
J
Jiri Podlipny, MD, Ph.D.
F
Frantisek Nekvapil, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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