A Prospective Cohort Register Study for Validation of Caprini Score in Patients Undergoing Varicose Vein Surgery

What this Trial Is About

This research aims to validate the Caprini score in adult patients undergoing various types of varicose vein surgeries, including endovascular procedures like endovenous laser treatment (EVLT), radiofrequency ablation (RFA), and ultrasound-guided foam sclerotherapy (USFS). The goal is to identify patients at higher risk of postoperative venous thromboembolism (VTE) who might benefit from preventive anticoagulation. The study is conducted as a prospective cohort based on an ongoing registry of chronic venous disease treatments. Participants will undergo one of several varicose vein surgeries with or without prophylaxis and will be monitored for venous thromboembolic complications. Procedures include EVLT, RFA, ultrasound-guided foam sclerotherapy, high ligation and stripping, miniphlebectomy, and sclerotherapy. Post-procedure, some patients may use graduated compression stockings or receive low-molecular-weight heparin depending on physician decision. Follow-up is planned for 2 to 4 weeks after surgery, including mandatory duplex ultrasound. During the 4-week follow-up, participants will be assessed for symptomatic and asymptomatic deep vein thrombosis, pulmonary embolism, thermal-induced thrombosis after thermal ablations, and bleeding events. Clinical evaluations, ultrasound exams, and other routine observations will be performed to monitor for any VTE episodes and safety outcomes. The primary outcome is any VTE event within 4 weeks, with secondary outcomes including bleeding and mortality. The study is sponsored by Pirogov Russian National Research Medical University.

Caprini Score in Venous Surgery: a Prospective Cohort Study