Actively Recruiting
Effects of Steep Trendelenburg and Pneumoperitoneum on Cardiac Performance During Robotic-assisted Surgery in Patients With Normal and Low Ejection Fraction
Led by Karlstad Central Hospital · Updated on 2026-02-12
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Robotic-assisted laparoscopic surgery is increasingly used, especially for older and more fragile patients who may not tolerate major open surgery. This research focuses on the challenges to heart function during robotic surgery involving a steep 30-degree head-down tilt (Trendelenburg position), which can increase the heart's workload. The study compares patients with normal heart function to those with systolic heart failure under these conditions to understand circulatory effects better. Participants undergo preoperative echocardiography to classify heart function as normal or decreased (ejection fraction 45% or lower). During surgery, heart performance is monitored using an esophageal doppler device, while brain oxygen levels are measured by optical spectrophotometry. Measurements are taken before anesthesia, during Trendelenburg positioning, at the start of the pneumoperitoneum (carbon dioxide insufflation), and after returning to a flat position. Throughout the study, standard anesthesia parameters and various cardiac output measures are recorded to analyze heart workload changes. The main outcome is the change in stroke volume during Trendelenburg positioning and pneumoperitoneum within 15 minutes. Secondary outcomes include changes in systemic vascular resistance, pulse pressure variation, peak velocity, stroke volume variation, flow time corrected, and regional brain oxygen saturation. This observational study helps identify which patients may be at risk of heart complications during robotic surgery and informs safer surgical decisions.
CONDITIONS
Brief Title
Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Consecutive patients scheduled for robotic surgery with Trendelenburg positioning
You will not qualify if you...
- Age under 18 years
- Dementia
- Unable to provide written consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 day before surgery
Participants undergo a transthoracic echocardiography before surgery to measure heart ejection fraction and classify heart function.
1 visit (in-person)
Duration - Duration of surgery (approximately several hours)
During robotic-assisted surgery, participants have cardiac performance and brain oxygen saturation monitored at multiple time points including before anesthesia, during Trendelenburg position, pneumoperitoneum, and after return to supine position.
Continuous monitoring during surgery
Trial Site Locations
Total: 1 location
1
Dpt of Anesthesiology&Intensive Care; Central Hospital of Karlstad
Karlstad, Värmland County, Sweden, 65230
Actively Recruiting
Research Team
R
Ragnar N Henningsson, Associate Professor
A
Ann-Sofie Lorentzon, ND
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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