Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
ID06336746

Effects of Steep Trendelenburg and Pneumoperitoneum on Cardiac Performance During Robotic-assisted Surgery in Patients With Normal and Low Ejection Fraction

Led by Karlstad Central Hospital · Updated on 2026-02-12

80

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Robotic-assisted laparoscopic surgery is increasingly used, especially for older and more fragile patients who may not tolerate major open surgery. This research focuses on the challenges to heart function during robotic surgery involving a steep 30-degree head-down tilt (Trendelenburg position), which can increase the heart's workload. The study compares patients with normal heart function to those with systolic heart failure under these conditions to understand circulatory effects better. Participants undergo preoperative echocardiography to classify heart function as normal or decreased (ejection fraction 45% or lower). During surgery, heart performance is monitored using an esophageal doppler device, while brain oxygen levels are measured by optical spectrophotometry. Measurements are taken before anesthesia, during Trendelenburg positioning, at the start of the pneumoperitoneum (carbon dioxide insufflation), and after returning to a flat position. Throughout the study, standard anesthesia parameters and various cardiac output measures are recorded to analyze heart workload changes. The main outcome is the change in stroke volume during Trendelenburg positioning and pneumoperitoneum within 15 minutes. Secondary outcomes include changes in systemic vascular resistance, pulse pressure variation, peak velocity, stroke volume variation, flow time corrected, and regional brain oxygen saturation. This observational study helps identify which patients may be at risk of heart complications during robotic surgery and informs safer surgical decisions.

CONDITIONS

Brief Title

Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery.

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Consecutive patients scheduled for robotic surgery with Trendelenburg positioning
Not Eligible

You will not qualify if you...

  • Age under 18 years
  • Dementia
  • Unable to provide written consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Up to 1 day before surgery

Participants undergo a transthoracic echocardiography before surgery to measure heart ejection fraction and classify heart function.

1 visit (in-person)

Monitoring

Duration - Duration of surgery (approximately several hours)

During robotic-assisted surgery, participants have cardiac performance and brain oxygen saturation monitored at multiple time points including before anesthesia, during Trendelenburg position, pneumoperitoneum, and after return to supine position.

Continuous monitoring during surgery

Trial Site Locations

Total: 1 location

1

Dpt of Anesthesiology&Intensive Care; Central Hospital of Karlstad

Karlstad, Värmland County, Sweden, 65230

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Research Team

R

Ragnar N Henningsson, Associate Professor

A

Ann-Sofie Lorentzon, ND

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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