Actively Recruiting
Cardiometabolic Disease and Substrate Metabolism
Led by University of Tennessee Graduate School of Medicine · Updated on 2026-05-04
50
Participants Needed
1
Research Sites
85 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.
CONDITIONS
Official Title
Cardiometabolic Disease and Substrate Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 45 years
- Any pre-pregnancy BMI
- At least one high or moderate risk factor for pre-eclampsia based on ACOG and USPSTF guidelines
- Willing to take aspirin therapy
- Agree to undergo 2-hour oral glucose tolerance test and other study procedures
- Gestational age less than 18 weeks at enrollment
- Ability to speak, read, and communicate in English
You will not qualify if you...
- Diagnosis of type 1 or type 2 diabetes mellitus
- Current gestational diabetes mellitus
- Active platelet disorders or bleeding problems
- Thrombophilia
- Current use of NSAIDs for other conditions
- Use of immune-modulating drugs or biologics
- Current or recent use of steroids
- Use of anticoagulation therapy
- Medical reasons preventing aspirin use
- Molar pregnancy
- Kidney disease
- Unable or unwilling to give informed consent
- Current psychiatric illness or social issues limiting study compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Tennessee Graduate School of Medicine
Knoxville, Tennessee, United States, 37920
Actively Recruiting
Research Team
J
Jill M Maples, PhD
CONTACT
H
Hana O El-Messidi, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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