Actively Recruiting
Development and Validation of a Prediction Model for Adverse Pregnancy Outcomes in Women With Aplastic Anemia
Led by Peking University People's Hospital · Updated on 2025-12-01
300
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
P
Peking University People's Hospital
Lead Sponsor
T
Tianjin Medical University General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Pregnant women with aplastic anemia (AA), a rare blood disorder causing bone marrow failure and low blood counts, face serious risks including heavy bleeding, infections, and complications for their babies like preterm birth and restricted growth. This research aims to develop and validate a tool to predict adverse pregnancy outcomes in women with AA, helping guide early clinical decisions and improve health for mothers and infants. The study combines retrospective and prospective data collection across multiple centers to address the current lack of comprehensive data in this area. The study involves observing pregnant women diagnosed with AA either before or during their pregnancy. Researchers will gather baseline information and diagnostic data, then follow participants regularly through questionnaires, phone calls, video consultations, online platforms, and in-person visits. They will record treatments, other health conditions, and pregnancy outcomes, aiming to build a prediction model for adverse outcomes. Participants will be monitored from their first hospital visit during pregnancy until 42 days after delivery. Data collected includes clinical assessments and neonatal Apgar scores shortly after birth. The study will provide detailed information on the health and risks for mothers and babies affected by AA during pregnancy, helping improve care strategies. The total participation duration varies depending on the timing of enrollment and delivery.
CONDITIONS
Brief Title
A Prediction Model in Pregnant Women With Aplastic Anemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women who had aplastic anemia before pregnancy
- Pregnant women with newly diagnosed aplastic anemia during pregnancy
You will not qualify if you...
- Age less than 20 years
- Without coagulation series results
- Termination of pregnancy before 20 weeks of gestation
- Multiple pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - From first hospital visit during pregnancy to delivery
Baseline patient information and diagnostic data are collected to understand participants' health status related to aplastic anemia during pregnancy.
1 to 2 visits depending on clinical needs
Duration - From first hospital visit during pregnancy to 42 days after delivery
Participants are followed prospectively through questionnaires, telephone interviews, video consultations, online platforms, and in-person visits to monitor health outcomes and treatment regimens.
Regular follow-ups via multiple methods including in-person and remote contacts
Trial Site Locations
Total: 1 location
1
Peking University People's Hospital
Beijing, China, 100044
Actively Recruiting
Research Team
X
Xiaohui Zhang, MD
Q
Qiuyu Guo, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here