Actively Recruiting
Cardiometabolic Health in First Time Pregnancy
Led by Cambridge University Hospitals NHS Foundation Trust · Updated on 2024-04-09
3500
Participants Needed
7
Research Sites
1540 weeks
Total Duration
On this page
Sponsors
C
Cambridge University Hospitals NHS Foundation Trust
Lead Sponsor
U
University of Cambridge
Collaborating Sponsor
AI-Summary
What this Trial Is About
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth restriction (baby being small) have twice the risk of developing heart disease and diabetes later in life, compared to women who have a healthy pregnancy. This study aims to assess risk factors for heart disease and diabetes in women who are actively trying to conceive, before and during their pregnancy, and 9-12 months after delivery of their baby, to see whether placental syndromes make a difference to their heart health. This will allow us to understand, if, and how, placental syndromes increase the risk of heart disease and diabetes, and, therefore, how best to reduce this risk and potentially prevent placental syndromes in the future. The investigators will also recruit women who are NOT planning pregnancy, as a control group.
CONDITIONS
Official Title
Cardiometabolic Health in First Time Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Nulliparous (no previous pregnancy beyond 20 weeks' gestation)
- Actively considering pregnancy within approximately 12 months (Pregnancy arm)
- Not planning to conceive during the next 18 months (Non-pregnancy arm)
- Aged between 18 and 45 years
- Ability to consent and willing to participate
You will not qualify if you...
- Currently pregnant
- Established infertility
- Planning or actively using fertility treatments (e.g., IVF, ICSI, FET, IUI)
- Assigned male sex at birth
- Autoimmune diseases such as rheumatoid arthritis or lupus
- Thrombophilia
- Type 1 diabetes
- Known advanced chronic kidney disease (stages 4-5)
- Malignant hypertension
- Clinically manifest cardiovascular disease (e.g., previous heart attack or stroke)
- Active cancer or currently receiving cancer treatment (other than skin cancer)
- Any other condition preventing full participation in the study
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
2
NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Actively Recruiting
3
University College London Hospitals NHS Foundation Trust
London, United Kingdom, NW1 2BU
Not Yet Recruiting
4
King's College Hospital NHS Foundation Trust
London, United Kingdom, SE5 9RS
Not Yet Recruiting
5
St George's University Hospitals NHS Foundation Trust
London, United Kingdom, SW17 0QT
Not Yet Recruiting
6
Imperial College Healthcare NHS Trust
London, United Kingdom, W2 1NY
Actively Recruiting
7
Manchester University NHS Foundation Trust
Manchester, United Kingdom, M13 9WL
Not Yet Recruiting
Research Team
H
Heike Templin
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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