Actively Recruiting
The Impact of Cardiometabolic Factors on Coronary Artery and Cardiovascular Diseases: a Prospective Cohort Study
Led by Ruijin Hospital · Updated on 2024-08-06
3000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The trial investigates the relationship between cardiometabolic factors and coronary artery diseases in patients with metabolic abnormalities such as diabetes, prediabetes, obesity, chronic kidney disease, and hyperuricemia. It is a prospective cohort study conducted at a single center, focusing on how these factors impact coronary disease progression and cardiovascular health over time. Participants with established coronary artery disease or metabolic disorders are enrolled and observed to assess changes in their coronary plaque and lesion severity over 12 months. Researchers also monitor cardiovascular events for up to five years to understand long-term outcomes linked to these metabolic conditions. During the study, participants undergo evaluations to measure coronary plaque progression and lesion severity, along with assessments of plaque characteristics. The study includes follow-up visits and monitoring to track cardiovascular events and disease progression. Participation spans from initial enrollment through at least one year for primary measurements and up to five years for secondary outcomes, providing a detailed understanding of disease development and risk factors.
CONDITIONS
Brief Title
CArdioMetabolism and Atherosclerotic PlaqUe progreSsion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years
- Established coronary artery disease or metabolic disorders, including type 2 diabetes, prediabetes, obesity, chronic kidney disease, hyperuricemia, or dyslipidemia
- Type 2 diabetes diagnosed by HbA1c 7 6.5%, fasting plasma glucose 7 7.0 mmol/l, 2h plasma glucose during OGTT 7 11.1 mmol/l, or receiving glucose-lowering agents
You will not qualify if you...
- Severe liver failure (Child-Pugh grade B to C)
- Severe anemia (hemoglobin < 60g/L)
- Familial hypercholesterolemia
- Active malignant tumor
- Active autoimmune diseases on corticosteroids
- Acute or chronic infection
- Life expectancy less than 1 year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants who undergo routine care are observed to assess coronary plaque progression and cardiovascular events.
Visits as part of routine healthcare
Trial Site Locations
Total: 1 location
1
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China, 200025
Actively Recruiting
Research Team
X
Xiaoqun Wang, M.D., Ph.D.
S
Shuo Feng, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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