Effects of Lifestyle and Drug Treatments on Heart and Blood Vessel Health in Women with Polycystic Ovary Syndrome

What this Trial Is About

Researchers are studying women with Polycystic Ovary Syndrome PCOS to investigate markers related to blood vessel, heart muscle, and inner vessel lining function. The study looks at these markers both before and during a glucose tolerance test, as well as changes after treatment. It explores how metabolic and hormonal abnormalities in PCOS affect these markers and evaluates the impact of different treatments over time. Participants will be divided into four groups one group will receive lifestyle changes combined with a GLP-1 receptor agonist drug, another will receive lifestyle changes with an oral contraceptive, a third group will receive lifestyle changes with metformin, and the last group will receive lifestyle changes alone. After six months of treatment, the same tests will be repeated to observe changes. Tests include glucose and insulin levels, arterial stiffness, heart function using echocardiography, blood vessel dilation, and hormone levels. During the study, women will undergo detailed measurements at baseline, during the oral glucose tolerance test at multiple time points, and after six months of treatment. These assessments include blood tests, heart ultrasound scans, and blood vessel function tests. Researchers will track changes in heart strain, arterial stiffness, and blood vessel lining thickness as primary outcomes. Secondary outcomes include changes in coronary flow and blood vessel dilation. The study will last over a year with follow-up assessments at six and twelve months.

Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS