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Cardiovascular Outcomes and Risk Evaluation Among Recipients of Hematopoietic Stem Cell Transplantation (CORE-HCT): A Prospective Multicenter Observational Study
Led by Peking University People's Hospital · Updated on 2026-01-16
10000
Participants Needed
16
Research Sites
26 weeks
Total Duration
On this page
Sponsors
P
Peking University People's Hospital
Lead Sponsor
H
Hematology Hospital of Chinese Academy of Medical Sciences (Hematology Research Center of Chinese Academy of Medical Sciences)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a prospective, multicenter observational study focused on patients who have received hematopoietic stem cell transplantation. The study aims to collect detailed information on clinical characteristics, laboratory results, management approaches, and outcomes related to cardiovascular events after transplantation. This research will help understand the risks and complications associated with stem cell transplant recipients over time. Participants are patients who have undergone allogeneic hematopoietic stem cell transplantation at participating medical centers. The study does not involve any experimental treatment but follows these patients to observe their health status and cardiovascular outcomes. There is no intervention administered; instead, data is collected through routine medical care and follow-ups. During the study, researchers will prospectively gather data on major adverse cardiovascular events at multiple time points: 30 days, 100 days, 3 months, 6 months, 1 year, 3 years, and 5 years post-transplant. Additional outcomes include overall survival, event-free survival, and complications related to the transplantation. The study involves regular assessments and monitoring to evaluate health status and cardiovascular risks over several years, with participation lasting up to five years after transplantation.
CONDITIONS
Brief Title
Cardiovascular Outcomes and Risk Evaluation Among Recipients of Hematopoietic Stem Cell Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who undergo hematopoietic cell transplantation at any of the participating medical centers.
You will not qualify if you...
- Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data.
- Patient request to withdraw from the study.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 5 years post transplantation
Participants who undergo hematopoietic stem cell transplantation are observed for cardiovascular events and overall survival.
Visits at 30 days, 100 days, 3 months, 6 months, 1 year, 3 years, and 5 years post transplantation
Trial Site Locations
Total: 16 locations
1
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
2
Peking University First Hospital
Beijing, Beijing Municipality, China
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3
Peking University People's Hospital
Beijing, Beijing Municipality, China
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4
Peking University Third Hospital
Beijing, Beijing Municipality, China
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5
Xinqiao hospital of the third military medical university
Chongqing, Chongqing Municipality, China
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6
Sun Yat-sen University Cancer Center, Sun Yat-sen University
Guangzhou, Guangdong, China
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7
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
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8
First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
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9
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
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10
Tongji Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China
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11
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
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12
First Affiliated Hospital Xi'an Jiaotong University
Xi'an, Shaanxi, China
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13
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
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14
Hematology Hospital of Chinese Academy of Medical Sciences (Hematology Research Center of Chinese Academy of Medical Sciences)
Tianjin, Tianjin Municipality, China
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15
First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
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16
First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
X
Xiao Hui Zhang
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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