Actively Recruiting
Characteristics and Inflammatory Markers in Children With Eosinophilic Esophagitis (EoE)
Led by University of California, San Diego · Updated on 2026-06-04
1500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research focuses on children diagnosed with eosinophilic esophagitis (EoE), a condition involving inflammation of the esophagus. The study aims to understand the natural history, clinical characteristics, and inflammatory markers of EoE in pediatric patients. It is an observational study conducted at a single center, gathering detailed patient data and biological samples to explore disease progression and molecular changes associated with different disease types. Participants are recruited during routine clinic and endoscopy visits at Rady Children's Hospital. Medical information including symptoms, endoscopy results, histopathology, medical history, lab tests, and imaging findings are recorded in a database. Blood and biopsy samples are collected for analysis of inflammatory molecules and for studying structural cells. This sample collection helps build a repository for future research into EoE-related markers and disease mechanisms. During the study, participants undergo regular clinical care visits where data on symptoms, endoscopy, and histology are tracked over ten years. Researchers will also monitor inflammatory markers in blood and biopsies over this period. The study involves detailed medical evaluations, sample collection, and database updates to better understand the disease course, treatment responses, and molecular characteristics in children with EoE.
CONDITIONS
Brief Title
Characteristics and Inflammatory Markers in Children With Eosinophilic Esophagitis (EoE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a known EoE diagnosis
- Complain of dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications)
- Present with food impaction
- Present with esophageal stricture
- Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 10 years
Participants who undergo routine clinical care for eosinophilic esophagitis (EoE) are observed. Medical information including clinical symptoms, endoscopy, histopathology, medical and surgical history, lab and imaging findings are collected. Blood and biopsy specimens are obtained for analysis and storage to study disease progression and inflammatory markers.
Clinic and/or endoscopy visits as part of routine care
Trial Site Locations
Total: 1 location
1
Rady Children's Hospital San Diego
San Diego, California, United States, 92123
Actively Recruiting
Research Team
K
Kira Chaiboonma, BS
S
Seema S Aceves, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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