Diagnosis of tuberculosis from smear-negative presumptive TB cases using Xpert MTB/Rif assay: a cross-sectional study from Nepal.
Priyatam Khadka, Januka Thapaliya, Ramesh Bahadur Basnet...
https://pubmed.ncbi.nlm.nih.gov/31888522Actively Recruiting
All Genders
ID06531772
Characteristics and Outcomes of Tuberculosis and HIV Co-infections in Upper Egypt
Led by Assiut University · Updated on 2024-08-01
100
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to investigate the characteristics and outcomes of tuberculosis (TB) and HIV co-infections in Upper Egypt. It focuses on people living with HIV who are at risk for several opportunistic infections depending on their immune system status and regional infection patterns. Tuberculosis is the most common opportunistic infection among HIV-positive individuals, especially in developing countries, and is a leading cause of death in this population worldwide. The study observes two groups: patients with tuberculosis alone and those with both tuberculosis and HIV co-infection. Participants receive a full regimen of antitubercular drugs for at least six months or longer if medically justified. The study does not involve experimental treatments but monitors existing therapy and outcomes over time. Participants will be followed to evaluate their response to tuberculosis treatment over six months, with additional monitoring of pulmonary complications over one year. Researchers will collect data on cure rates and complications to better understand the impact of co-infection. The study involves clinical assessments and laboratory diagnosis to track outcomes and inform future care strategies.
CONDITIONS
Brief Title
Characteristics and Outcomes of TB and HIV Co-infections
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
- Laboratory diagnosis of TB-HIV co-infection
You will not qualify if you...
- Patients refusing to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Monitoring
Duration - 6 months or longer as justified by patient condition
Participants with tuberculosis and HIV co-infections are observed to investigate characteristics and outcomes while receiving standard care.
Long-term Monitoring
Duration - Up to 1 year
Participants are followed to assess pulmonary complications associated with tuberculosis over an extended period.
Trial Site Locations
Total: 1 location
1
Faculty of Medicine, Assiut University
Asyut, Egypt, 711111
Actively Recruiting
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Research Team
W
Waleed MD Gamal Elddin Khaleel, Ass. Prof.
M
Manal MD Ahmed Mahmoud, Ass. Prof.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Profile of HIV associated tuberculosis at a tertiary institute in setting of free anti-retroviral therapy.
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https://pubmed.ncbi.nlm.nih.gov/20329424Diagnosis and treatment of tuberculosis in adults with HIV.
Qiaoli Yang, Jinjin Han, Jingjing Shen...
https://pubmed.ncbi.nlm.nih.gov/36107594