Study of Immune Cells in Blood and Tumors of Adults With Malignant Brain Tumors Undergoing Neurosurgery

What this Trial Is About

This research aims to study the immune cells in patients with malignant brain tumors, including primary tumors like glioblastoma multiforme and metastatic brain tumors. Researchers want to understand the types and behavior of immune cells circulating in the blood and those present within the tumor. The goal is to see how these immune profiles relate to cancer outcomes, which may help improve understanding of these aggressive brain cancers. The study involves collecting blood samples before neurosurgical treatment and at several follow-up times 3, 6, 9, and 12 months after surgery. Tumor samples obtained during surgery will also be analyzed to study immune T cells inside the tumor. The blood samples will be tested using flow cytometry to classify leukocyte subtypes and immune profiles, while tumor samples will undergo immunohistochemical analysis to examine immune cell distribution. Participants will provide blood samples before surgery and during follow-up visits for up to one year. Researchers will measure the count and type of leukocytes and tumor-infiltrating lymphocytes at baseline and after surgery. The study will monitor changes in immune cells over time and correlate these findings with patients clinical progression. This is a prospective observational study involving about 200 adult patients undergoing neurosurgical treatment for malignant brain tumors.

Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors