Actively Recruiting
Glutamate Excitotoxicity and Its Role in Glioblastoma Biology
Led by IRCCS San Raffaele · Updated on 2025-06-11
50
Participants Needed
1
Research Sites
486 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasion
CONDITIONS
Official Title
Glutamate Excitotoxicity and Its Role in Glioblastoma Biology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant).
- Patient able to provide informed consent.
You will not qualify if you...
- Age less than 18 years
- Liver disease
- Severe anemia (Hb less than 8mg/dl)
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
IRCCS San Raffaele Scientific Institute
Milan, Milan, Italy, 20132
Actively Recruiting
Research Team
S
Sincinelli Laura
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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