Actively Recruiting
Children's Health, Respiratory Inflammation and Short-term Air Pollution
Led by Queen Mary University of London · Updated on 2026-04-21
330
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
Sponsors
Q
Queen Mary University of London
Lead Sponsor
I
Imperial College London
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how physical activity in areas with high air pollution affects children's lung health compared to rest in the same conditions. The study involves children aged 7 to 11 from primary schools in areas with different pollution levels, aiming to understand the impact of short-term air pollution on respiratory inflammation. This is a randomized, interventional study conducted by Queen Mary University of London. The study will include 330 children from 10 schools categorized by pollution levels. Children will participate in two types of outdoor sessions: a 90-minute physical education (PE) lesson and a 90-minute sedentary science lesson. During these sessions, children will wear activity monitors to track movement, while air pollution levels are measured in the playground. Lung health and immune responses will be assessed before, immediately after, and 24 hours post-exposure through breathing tests and nasal samples. Participants will be assessed at school on two separate days, including measurements of height, weight, and lung function using oscillometry. Nasal samples will be collected to analyze immune responses to pollution. The study measures airway resistance and small airway resistance to evaluate lung function changes. Overall participation will take about four hours, and the research seeks to compare respiratory effects between children in higher and lower pollution environments.
CONDITIONS
Brief Title
Children's Health, Respiratory Inflammation and Short-term Air Pollution
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Attending schools in Central and East London that have been recruited to the study
You will not qualify if you...
- Not able to engage with PE lessons on safety grounds, as reported by parents
- Children with learning or physical disabilities that prevent giving informed assent or carrying out study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 days
Participants take part in two outdoor lessons—a PE lesson and a science lesson—in random order, while wearing activity monitors. Lung health assessments, including height, weight, breathing tests, and nasal samples, are performed before and immediately after each lesson to evaluate changes in lung function and immune response.
2 visits (in-person) on consecutive days
Trial Site Locations
Total: 1 location
1
Faculty of Medicine and Dentistry
London, United Kingdom, E1 2AB
Actively Recruiting
Research Team
J
James Scales, PhD
A
Abigail Whitehouse, MD,PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
2
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