Association between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study.
Yongbing Sun, Xin Qi, Xuan Wang...
https://pubmed.ncbi.nlm.nih.gov/38267987Actively Recruiting
Led by Beijing Jishuitan Hospital · Updated on 2025-08-17
30000
Participants Needed
6
Research Sites
26 weeks
Total Duration
B
Beijing Jishuitan Hospital
Lead Sponsor
C
Chinese PLA General Hospital
Collaborating Sponsor
Researchers are conducting a nationwide, multi-center study in China to combine low dose chest CT scan data with Quantitative Computed Tomography (QCT) technology. The goal is to measure bone mineral density (BMD) of the spine, visceral adipose tissue (VAT), and liver fat content in people undergoing health checks. This study aims to assess how well QCT works in health screenings and to understand the rates of osteoporosis, obesity, and liver steatosis in the health check population across China. The study uses standard low dose chest CT scans commonly performed in health check centers to gather raw CT data. QCT then analyzes this data to quantify BMD, VAT, and liver fat content. These measurements help in diagnosing osteoporosis, evaluating obesity, and assessing liver steatosis without additional scanning procedures. The study collects this information from multiple centers throughout China, enhancing the data's breadth and reliability. Participants aged 30 to 90 years who undergo low dose chest CT scans as part of health checks are involved. The study monitors spinal volumetric bone mineral density as the primary outcome over two years. Secondary outcomes include measurements of visceral adipose tissue and liver fat, also tracked over two years. Researchers use this data to evaluate health status and disease prevalence. Pregnant women and individuals with metal implants in the CT scan area are excluded to ensure accurate imaging and safety.
CONDITIONS
China Health Big Data
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At baseline
Participants undergo low dose chest CT scans and quantitative computed tomography (QCT) assessments to measure bone mineral density, visceral fat, and liver fat content.
1 visit (in-person)
Duration - Up to 2 years
Participants are observed over time to evaluate the prevalence of osteoporosis, obesity, and liver steatosis based on imaging data collected.
Follow-up assessments may occur depending on study schedule
Total: 6 locations
1
Wu Hu Yijishan Hospital
Wuhu, Anhui, China, 100035
Actively Recruiting
2
Beijing Jishuitan hospital
Beijing, Beijing Municipality, China, 100035
Actively Recruiting
3
The first affiliated hospital of Guiyang Medical University
Guiyang, Guizhou, China
Actively Recruiting
4
The first affiliated hospital of Zhengzhou University
Zhengzhou, Henan, China
Actively Recruiting
5
Hua Shan hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
6
Shanghai Ruijin hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
X
xiaoguang cheng, md
X
xiaoxia fu, md
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Yongbing Sun, Xin Qi, Xuan Wang...
https://pubmed.ncbi.nlm.nih.gov/38267987Yongbing Sun, Xin Qi, Xinbei Lin...
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https://pubmed.ncbi.nlm.nih.gov/33145809