Actively Recruiting
Comparing Tear Proteomics Profile in Dry Eye Disease pre-and Post-treatment With Low Level Light Therapy
Led by Singapore National Eye Centre · Updated on 2026-01-09
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how low-level light therapy works and to identify markers linked to good treatment responses in people with dry eye disease and meibomian gland dysfunction. The therapy uses a specialized eye-light device that delivers light energy to the meibomian gland cells to slow aging, improve tear stability, and reduce inflammation. The study is observational and focuses on the changes in tear proteins before and after treatment. Participants will undergo low-level light therapy using an advanced eye-light device. The therapy is delivered through this device to target the meibomian glands. The study compares tear proteomics profiles at the start and after approximately three months following treatment. There are no additional treatment arms or placebo groups since this is an observational study. During the study, participants will have their tear proteins analyzed at the baseline visit and again three months later. Researchers will monitor changes in tear proteomics to assess treatment effects. Participants must be able to give informed consent and meet other eligibility requirements. The total duration of involvement includes the baseline and post-treatment assessments around three months apart.
CONDITIONS
Brief Title
Comparing Tear Proteomics Profile in Dry Eye Disease pre-and Post-treatment With Low Level Light Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be eligible for, and have consented for low level light therapy
- Must not have presented to the clinic for an acute eye problem such as visual loss or painful eye
- Ability to give informed consent
- Age 21 years or older
You will not qualify if you...
- Unable or decline to give consent
- Age less than 21 years old
- Presented to the clinic for an acute eye problem such as visual loss or painful eye
- Not suitable for low level light therapy, including:
- Pregnancy
- Fitted with pacemakers, metal, electrical, acoustic prosthetics
- Epilepsy, cardiac rhythm or frequency disorders
- Fever, thrombophlebitis or acute phlebitis of the legs, large-sized varicose veins, or venous surgery within 2 months
- Uncontrolled hypertension or severe diabetes
- Open wounds on eyelid or skin
- Evolving cancer or hepatitis
- Blood anticoagulant or coagulation defect
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 3 months
Participants undergoing low level light therapy are observed to compare tear proteomics profiles before and after treatment.
1 baseline visit and 1 follow-up visit at 3 months (+3 weeks)
Trial Site Locations
Total: 1 location
1
Singapore Eye Research Insititute
Singapore, Singapore
Actively Recruiting
Research Team
L
Louis Tong Tong, PhD
J
Jiayi Lee, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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