Actively Recruiting
A Multicenter Clinical Study on a New Treatment Model Combining Surgical Techniques, Perioperative Care, and Postoperative Rehabilitation for Elderly Lung Cancer Patients
Led by Peking University People's Hospital · Updated on 2026-06-08
1000
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to improve treatment for elderly patients with lung cancer by developing a comprehensive, whole-process care model. The study focuses on creating a large clinical registry with data from over 2000 patients across at least 30 centers. It seeks to build risk prediction models for surgery and to optimize surgical and perioperative treatments, integrating both Western and traditional Chinese medicine approaches. The goal is to enhance outcomes and personalize care for elderly lung cancer patients. Participants are assigned to one of three surgical treatment groups: standard lobectomy, segmentectomy, or wedge resection, each combined with mediastinal lymph node sampling. Patients are evaluated and stratified by tumor size and geriatric risk scores before surgery. Postoperative care includes tailored perioperative management based on minimal residual disease monitoring and biomarker results. The study also develops personalized rehabilitation plans supported by a multidisciplinary team and remote monitoring technology. Throughout the study, participants will undergo comprehensive assessments including geriatric evaluations, imaging, pathology, and biomarker testing. Researchers will monitor overall survival for up to five years after surgery and track major postoperative complications within 90 days. The trial includes regular follow-up visits to evaluate treatment safety, effectiveness, and rehabilitation progress. This long-term involvement aims to establish an optimized, integrated treatment model specifically for elderly lung cancer patients.
CONDITIONS
Brief Title
Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Confirmed non-small cell lung cancer eligible for curative surgical resection
- Complete preoperative geriatric comprehensive assessment data available
- Able to complete planned surgery and long-term follow-up
- Voluntarily signed informed consent form
You will not qualify if you...
- History of other malignant tumors within the past 5 years
- Severe heart, liver, kidney, or lung dysfunction preventing thoracic surgery
- Confirmed distant metastasis before surgery that prevents radical resection
- Uncontrolled severe infection or obvious coagulation disorders
- Severe psychiatric disorder or cognitive dysfunction interfering with treatment and follow-up
- Refusal of random assignment and postoperative regular monitoring
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day
Participants undergo one of three types of lung cancer surgery: lobectomy, segmentectomy, or wedge resection, each combined with mediastinal lymph node sampling.
1 surgical visit (in-person)
Duration - Up to 90 days postoperatively
Participants receive stratified adaptive perioperative management and personalized perioperative treatment based on postoperative minimal residual disease and biomarker status, with regular monitoring for complications and recovery.
Regular visits during the first 3 months post-surgery
Duration - Up to 5 years
Participants are followed to assess overall survival and long-term outcomes for up to 5 years after surgical resection.
Periodic follow-up visits over 5 years
Trial Site Locations
Total: 1 location
1
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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