Human Lesion Studies in the 21st Century.
Ralph Adolphs
https://pubmed.ncbi.nlm.nih.gov/27311080Actively Recruiting
Age: 18Years - 70Years
All Genders
ID04182087
Cognitive Function Assessment in Patients With Focal Brain Injury
Led by University Hospital, Grenoble · Updated on 2024-01-17
400
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University Hospital, Grenoble
Lead Sponsor
G
Grenoble Institut des Neurosciences
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research focuses on studying cognitive difficulties linked to specific brain injuries and their locations. The aim is to build a large database of patient behavioral responses during cognitive tasks to better understand brain function. The study includes patients with focal brain lesions caused by stroke or surgical removal of brain tissue, which affect functions like attention, language, memory, decision-making, and executive function. Participants will undergo cognitive tasks that assess various higher brain functions such as attention, language, memory, decision-making, and executive skills. These tasks are observational and involve patients who have had focal brain injuries either from stroke or brain surgery. The study collects data during routine visits scheduled at 3, 6, 12, or 24 months after the brain lesion, with up to four sessions lasting about two hours each. During the study, participants will perform cognitive tasks while their behavioral performance, including reaction times and error rates, is recorded. These assessments happen during routine follow-up visits over two years. Researchers will analyze this data to explore links between brain structures and cognitive functions. The total participation may involve up to four sessions, each lasting approximately two hours, to track changes over time and better understand cognitive deficits after brain injury.
CONDITIONS
Brief Title
Cognitive Function Assessment in Patients With Focal Brain Injury
Who Can Participate
Age: 18Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- Male and female patients aged 18 to 70 years
- A single, focal brain lesion confirmed by MRI, due to stroke or surgical removal
- Intellectual ability sufficient to understand and perform cognitive tasks
You will not qualify if you...
- Patients deprived of liberty
- Presence of a physical condition likely to affect cognitive abilities
- Pregnant or nursing women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 24 months post lesion
Participants complete cognitive tasks assessing attention, language, memory, decision-making, and executive functions during routine visits over two years following their brain injury.
Up to 4 routine visits at 3, 6, 12, or 24 months post lesion, each lasting about two hours
Trial Site Locations
Total: 1 location
1
University Hospital, Grenoble
Grenoble, France, 38043
Actively Recruiting
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Research Team
P
Philippe Kahane, MD, PhD
J
Julien Bastin, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
An integrative architecture for general intelligence and executive function revealed by lesion mapping.
Aron K Barbey, Roberto Colom, Jeffrey Solomon...
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L Clark, A Bechara, H Damasio...
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Pierre Deman, Manik Bhattacharjee, François Tadel...
https://pubmed.ncbi.nlm.nih.gov/30034332Lesion analysis of the brain areas involved in language comprehension.
Nina F Dronkers, David P Wilkins, Robert D Van Valin...
https://pubmed.ncbi.nlm.nih.gov/15037129Neural correlates of apathy in patients with neurodegenerative disorders, acquired brain injury, and psychiatric disorders.
Claire Kos, Marie-José van Tol, Jan-Bernard C Marsman...
https://pubmed.ncbi.nlm.nih.gov/27527825The functional neuroanatomy of working memory: contributions of human brain lesion studies.
N G Müller, R T Knight
https://pubmed.ncbi.nlm.nih.gov/16352402The attention system of the human brain: 20 years after.
Steven E Petersen, Michael I Posner
https://pubmed.ncbi.nlm.nih.gov/22524787Using human brain lesions to infer function: a relic from a past era in the fMRI age?
Chris Rorden, Hans-Otto Karnath
https://pubmed.ncbi.nlm.nih.gov/15378041On the validity of lesion-behaviour mapping methods.
Christoph Sperber, Hans-Otto Karnath
https://pubmed.ncbi.nlm.nih.gov/28782546