β-Amyloid may accumulate in the human brain after focal bacterial infection: An 18 F-flutemetamol positron emission tomography study.
Ane Gretesdatter Rogne, Ebba Gløersen Müller, Eirin Udnaes...
https://pubmed.ncbi.nlm.nih.gov/33131195Actively Recruiting
Age: 16Years +
All Genders
ID04938362
Cognitive Function and Fatigue After Brain Abscess Evaluated by FDG-PET and EEG
Led by University of Oslo · Updated on 2025-07-04
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Oslo
Lead Sponsor
O
Oslo University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Brain abscess is a localized bacterial or fungal infection in the brain that leads to a pus-filled cavity. Treatment involves neurosurgical drainage and long-term antibiotic therapy. Even after successful treatment, patients may experience lasting cognitive problems or mental fatigue, possibly due to ongoing inflammation or brain tissue damage caused by the abscess. This study aims to investigate these causes using advanced brain imaging and brain activity measurements. Participants are patients who have been treated for brain abscess and are divided into two groups: those experiencing cognitive dysfunction and/or fatigue, and those without these symptoms. They will undergo brain scans using [18F]deoxyglucose-positron emission tomography (FDG-PET) and electroencephalography (EEG) up to 10 years after treatment. FDG-PET scans help detect inflammation or changes in brain cell activity, while EEG measures brain wave patterns related to fatigue. During the study, patients will have cognitive tests at 2 and 12 months after treatment, followed by FDG-PET and EEG examinations. Researchers will monitor changes in brain inflammation and neuronal activity through these tests. The main outcomes include changes in FDG-PET signals indicating inflammation or neuronal changes and changes in EEG brain wave activity. The study helps understand whether cognitive problems and fatigue relate to brain tissue damage or inflammation, potentially guiding future treatments. Participants will be followed for at least one year.
CONDITIONS
Brief Title
Cognitive Function and Fatigue After Brain Abscess
Who Can Participate
Age: 16Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients who have completed treatment for brain abscess and agree to participate
- Age 16 years or older
You will not qualify if you...
- Unable to undergo neuropsychological testing due to unconsciousness
- Unable to undergo neuropsychological testing due to severe mental illness
- Diagnosis of dementia
- Unable to undergo FDG-PET due to claustrophobia
- Unable to undergo EEG due to panic attacks
- Age under 16 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Up to 10 years after brain abscess treatment
Participants undergo cognitive examination by a neuropsychologist, FDG-PET imaging, and EEG to assess brain function and inflammation after brain abscess treatment.
Assessments at approximately 2 months and 12 months after treatment
Long-term Monitoring
Duration - Up to 10 years after brain abscess treatment
Participants are observed over time to monitor changes in cognitive function, fatigue, FDG-PET signals, and EEG activity following brain abscess treatment.
Follow-up assessments depending on individual schedule over several years
Trial Site Locations
Total: 1 location
1
Oslo University Hospital
Oslo, Norway, 0450
Actively Recruiting
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Research Team
P
Peder H Utne
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Bacterial Brain Abscesses Expand Despite Effective Antibiotic Treatment: A Process Powered by Osmosis Due to Neutrophil Cell Death.
Daniel Dahlberg, Sverre Holm, Ellen Margaret Lund Sagen...
https://pubmed.ncbi.nlm.nih.gov/38084989Pro-inflammatory cytokines in cystic glioblastoma: A quantitative study with a comparison with bacterial brain abscesses. With an MRI investigation of displacement and destruction of the brain tissue surrounding a glioblastoma.
Bjørnar Hassel, Pitt Niehusmann, Bente Halvorsen...
https://pubmed.ncbi.nlm.nih.gov/35965529Brain Abscess Causes Brain Damage With Long-Lasting Focal Cerebral Hypoactivity that Correlates With Abscess Size: A Cross-Sectional 18 F-Fluoro-Deoxyglucose Positron Emission Tomography Study.
Ebba Gløersen Müller, Daniel Dahlberg, Bjørnar Hassel...
https://pubmed.ncbi.nlm.nih.gov/39526777