Study of Brain Function and Fatigue in Patients After Treatment for Brain Abscess Using FDG-PET and EEG

What this Trial Is About

Brain abscess is a localized bacterial or fungal infection in the brain that leads to a pus-filled cavity. Treatment involves neurosurgical drainage and long-term antibiotic therapy. Even after successful treatment, patients may experience lasting cognitive problems or mental fatigue, possibly due to ongoing inflammation or brain tissue damage caused by the abscess. This study aims to investigate these causes using advanced brain imaging and brain activity measurements. Participants are patients who have been treated for brain abscess and are divided into two groups those experiencing cognitive dysfunction andor fatigue, and those without these symptoms. They will undergo brain scans using 18Fdeoxyglucose-positron emission tomography FDG-PET and electroencephalography EEG up to 10 years after treatment. FDG-PET scans help detect inflammation or changes in brain cell activity, while EEG measures brain wave patterns related to fatigue. During the study, patients will have cognitive tests at 2 and 12 months after treatment, followed by FDG-PET and EEG examinations. Researchers will monitor changes in brain inflammation and neuronal activity through these tests. The main outcomes include changes in FDG-PET signals indicating inflammation or neuronal changes and changes in EEG brain wave activity. The study helps understand whether cognitive problems and fatigue relate to brain tissue damage or inflammation, potentially guiding future treatments. Participants will be followed for at least one year.

Cognitive Function and Fatigue After Brain Abscess