Study of Brain Changes and Thinking Problems in Adults with Colorectal Cancer Receiving Chemotherapy

What this Trial Is About

Researchers are studying how the brain changes in patients with colorectal cancer who receive cytotoxic chemotherapy treatments such as Capecitabine, Oxaliplatin, 5 fluorouracil, and Irinotecan. The purpose is to identify tests that can diagnose people at risk of developing difficulties with thinking and memory caused by their cancer treatment. This observational study focuses on cognitive impairment related to chemotherapy effects in adults with histologically confirmed colorectal tumors. Participants in this study will be those who have not previously received cytotoxic chemotherapy and will be monitored during their treatment for brain and cognitive changes. There are no experimental drugs or placebo groups since this is an observational study. The study collects information over a period of up to 7 years, including surveys and laboratory tests using the Proteome Profiler Human XL Cytokine Array Kit to track changes related to chemotherapy. During the study, participants will complete surveys and have biological samples analyzed to assess cognitive function and possible immune system changes. Researchers will review these measures to better understand chemotherapy-related cognitive decline. The study requires signed informed consent and follows strict privacy guidelines. Participation involves long-term observation without altering standard medical care, and data will be collected to improve diagnosis and support for patients experiencing chemo-brain symptoms.

Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy