Randomized Study of Cognitive Remediation Therapy Effects on Brain and Emotional Function in Adults with Schizophrenia

What this Trial Is About

Researchers are evaluating whether Cognitive Remediation Therapy CRT can improve attention, memory, and emotional regulation in people diagnosed with schizophrenia. This randomized controlled trial includes 60 participants 30 with schizophrenia and 30 healthy individuals matched by age and gender. The study focuses on understanding if a 12-week CRT program affects brain activity and emotional regulation, using EEG and galvanic skin response GSR measurements as key indicators. Participants with schizophrenia will be randomly assigned to either receive 12 weekly CRT sessions, each lasting about 60 minutes and targeting cognitive skills like working memory and executive function, or be placed on a waitlist without therapy during this period. Healthy participants will undergo baseline brain and emotional assessments but will not receive CRT. The study involves EEG recordings of brain responses and GSR to emotional stimuli, along with behavioral and cognitive tests. Throughout the study, all participants will complete memory, emotion recognition tasks, and self-report questionnaires on cognition and emotional well-being. Researchers will compare results before and after the intervention to measure changes in brain-based markers, cognitive function, and quality of life. Safety and adherence will be monitored, and the studys duration for participants is 12 weeks with assessments at baseline and post-intervention.

Cognitive Remediation Therapy for Schizophrenia: Effects on EEG and Emotional Regulation