Actively Recruiting
Pre and Post-Operative Cognitive Status in Patients Undergoing Surgery for Resection of Meningioma Associated With the Frontal and Temporal Lobes
Led by Ohio State University · Updated on 2026-05-22
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate long-term cognitive outcomes in patients undergoing surgery to remove a meningioma located in the frontal or temporal lobes of the brain. The study focuses on understanding how cognitive function changes before and after surgery through standardized cognitive tests. It includes adults aged 18 to 89 who are scheduled for meningioma resection by either craniotomy or an endoscopic endonasal approach. Participants will receive standard cognitive testing conducted by a speech-language pathology team at three time points: before surgery (baseline), six weeks after surgery, and one year after surgery. These tests include the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Montreal Cognitive Assessment (MoCA), PROMIS-29, and Neuro-QoL Cognitive Functions to assess various aspects of cognition. Throughout the study, patients will be monitored for changes in overall cognitive function as the primary outcome at one year after surgery. Secondary outcomes include cognitive function differences based on surgical approach and tumor location at the same time point. Participants are expected to attend follow-up visits for cognitive assessments and complete questionnaires to help researchers understand post-surgical cognitive changes over time.
CONDITIONS
Brief Title
Cognitive Status After Removal of Skull Base Meningioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject has a meningioma associated with the frontal or temporal lobes
- Subject is scheduled to undergo open craniotomy or Endoscopic Endonasal surgery
- Subject is 18 years of age or older
- Subject is psychosocially, mentally, and physically able to fully comply with the protocol, including follow-up visits and informed consent
- Previous surgery does not exclude the patient as a new baseline cognitive evaluation will occur
You will not qualify if you...
- Patient is a prisoner
- Patient is 90 years of age or older
- Pregnant women
- Previous radiation to the brain
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 week before surgery
Participants undergo baseline cognitive testing as part of standard care before surgery.
1 baseline visit (in-person)
Duration - Hospital stay duration varies
Participants undergo surgical resection of the meningioma via craniotomy or endoscopic endonasal approach.
1 surgical procedure visit (in-person)
Duration - 1 year
Participants complete follow-up cognitive testing at six weeks and one year after surgery to assess cognitive function.
2 visits (in-person) at 6 weeks and 12 months post-surgery
Trial Site Locations
Total: 1 location
1
Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
E
Emma Kurtz, BS
U
Uchechi Okafor, BS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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