National Cohort Study of Adults and Children with Major Depressive Episode Assessing Sleep, Biological Rhythms, and Psychiatric Conditions

What this Trial Is About

Depressive disorders affect up to 20% of people worldwide and are a leading cause of disability, with significant impacts on quality of life, productivity, and healthcare use. Despite research efforts, no biomarkers have been adopted for diagnosis, progression, or treatment response. This study aims to create a national French cohort to better identify sleep and biological rhythm markers and define more consistent subgroups of patients with major depressive episodes, improving understanding of the conditions manifestations and causes. Participants will undergo detailed evaluations of psychiatric status, sleep, addiction, and circadian rhythms. Various measurements include sleep studies such as polysomnography and actigraphy, urine tests for hormones like melatonin and cortisol, and assessments of sleep stages and efficiency. These evaluations aim to characterize sleep and rhythm abnormalities linked to depression and identify markers that can guide personalized treatment approaches. During the study, participants will be assessed mainly at inclusion for outcomes like REM sleep amount and other sleep stage characteristics. Researchers will collect extensive data on sleep patterns, biological markers, and psychiatric symptoms to understand depression better. The study involves no specific treatment but focuses on observational data collection, with participation potentially lasting several years as the cohort is followed over time.

Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders