Actively Recruiting
Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2024-05-16
1000
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients experiencing a major depressive episode to better understand sleep and biological rhythm markers linked to depression. This observational study is part of a French national cohort aiming to identify more uniform patient subgroups and clarify the characteristics and causes of depressive disorders, which affect up to 20% of people and have a significant impact on quality of life and health care. Despite efforts, no biomarkers have yet been adopted in clinical practice for diagnosis or treatment prediction. The study involves detailed evaluations of sleep and circadian rhythm disturbances in patients with depression, as these abnormalities are common and may influence relapse and overall functioning. Researchers assess a range of sleep characteristics, including REM sleep, slow-wave sleep stages, sleep efficiency, and movement during sleep, alongside urinary hormone levels and apnea indices. These assessments aim to better characterize depression subtypes and support more personalized psychiatric care. Participants undergo comprehensive psychiatric, addiction, sleep, and chronobiology assessments at inclusion. Measurements include polysomnography and actigraphy to assess sleep stages and quality, as well as biological samples to monitor hormonal markers. The main outcome measured is the amount of REM sleep. This observational study helps to identify markers linked to depression and supports future screening and treatment strategies, with participation duration varying by individual.
CONDITIONS
Brief Title
Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with a depressive episode diagnosed according to DSM-5 criteria, regardless of associated characteristics and comorbidities
- Adults and children
- Affiliated to social security
You will not qualify if you...
- Unable to understand or read French
- Medical condition that prevents completing questionnaires
- Unable to give informed consent (e.g., emergency condition)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At inclusion
Participants undergo detailed evaluations of sleep, circadian rhythms, and psychiatric status to characterize depressive disorders and related biomarkers.
1 in-person assessment visit
Duration - Up to 10 years
Participants are observed over time to track the evolution of depressive disorders and related sleep and rhythm abnormalities for research purposes.
Periodic visits as scheduled by study centers
Trial Site Locations
Total: 1 location
1
Hôpital Bichat Claude Bernard
Paris, France, 75018
Actively Recruiting
Research Team
P
Pierre Alexis GEOFFROY, PU-PH
J
Julia MARUANI
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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