HLA matching and corneal transplantation.
W J Stark, R D Stulting, R Thoft
https://pubmed.ncbi.nlm.nih.gov/3317044Completed
Phase 3
Age: 10Years +
All Genders
ID00000137
Collaborative Corneal Transplantation Studies (CCTS)
Led by National Eye Institute (NEI) · Updated on 2009-09-17
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To determine whether histocompatibility matching of corneal transplant donors and recipients can reduce the incidence of graft rejection in high-risk patients.
CONDITIONS
Brief Title
Collaborative Corneal Transplantation Studies (CCTS)
Who Can Participate
Age: 10Years +
All Genders
Eligibility Criteria
You may qualify if you...
Males and females age 10 years or older with two to four quadrants of corneal stroma vascularization or a history of allograft rejection in the eye considered for surgery were eligible for both studies in the CCTS.
Patients must have been willing to participate in 3 years of followup. No one was eligible for the CCTS who had a condition that would greatly increase the risk of nonrejection graft failure, such as xerophthalmia or severe exposure keratopathy. Also excluded were patients with systemic diseases or with medication usage that might alter their immune response.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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Published Research Related To This Trial
Sharing tissue typing information from the collaborative corneal transplantation studies.
W J Stark, R D Stulting, R F Meyer...
https://pubmed.ncbi.nlm.nih.gov/2655566The collaborative corneal transplantation studies (CCTS). Effectiveness of histocompatibility matching in high-risk corneal transplantation. The Collaborative Corneal Transplantation Studies Research Group.
https://pubmed.ncbi.nlm.nih.gov/1417537Corneal thickness changes after high-risk penetrating keratoplasty. Collaborative Corneal Transplantation Study Group.
P J McDonnell, C Enger, W J Stark...
https://pubmed.ncbi.nlm.nih.gov/8216018Effectiveness of histocompatibility matching in high-risk corneal transplantation: a summary of results from the Collaborative Corneal Transplantation Studies.
N Fink, W J Stark, M G Maguire...
https://pubmed.ncbi.nlm.nih.gov/8137435Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Collaborative Corneal Transplantation Studies Research Group.
M G Maguire, W J Stark, J D Gottsch...
https://pubmed.ncbi.nlm.nih.gov/8090456The association of lymphocytotoxic antibodies with corneal allograft rejection in high risk patients. The Collaborative Corneal Transplantation Studies Research Group.
A B Hahn, G N Foulks, C Enger...
https://pubmed.ncbi.nlm.nih.gov/7839424Patient-reported symptoms associated with graft reactions in high-risk patients in the collaborative corneal transplantation studies. Collaborative Corneal Transplantation Studies Research Group.
M T Kamp, N E Fink, C Enger...
https://pubmed.ncbi.nlm.nih.gov/7712736