Actively Recruiting
Biospecimen Collection and Donation to the AIDS and Cancer Specimen Resource A Companion Protocol to AIDS Malignancy Consortium Trials
Led by AIDS Malignancy Consortium · Updated on 2026-06-01
200
Participants Needed
8
Research Sites
260 weeks
Total Duration
On this page
Sponsors
A
AIDS Malignancy Consortium
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research collects blood and tissue samples from people living with HIV who are also diagnosed with certain cancers, as well as from people without HIV who have cancers linked to HIV. The aim is to better understand how biological or genetic factors connect HIV and AIDS-related cancers by studying these samples. This observational study is part of the AIDS Malignancy Consortium's effort to support future research through the AIDS and Cancer Specimen Resource (ACSR). Participants donate blood once, which is stored in a biobank for research use. They may also donate tissue samples from past or upcoming medical procedures. These biospecimens help researchers explore links between HIV and cancer. This study runs alongside other AMC clinical trials but also accepts donations from those not in those trials. During the study, participants will provide samples and consent to their use in research. The primary measure is the number of biospecimens collected over about ten years. There are no treatments or interventions beyond sample donation. The study involves monitoring how many samples are collected to support ongoing and future research efforts related to HIV and associated cancers.
CONDITIONS
Brief Title
Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be at least 18 years of age
- Participant must be HIV-positive and have a diagnosed malignancy
- If HIV-negative, participant must have a newly diagnosed or recurrent malignancy scientifically linked to AIDS-associated cancers such as classic Kaposi sarcoma, transplant-associated Kaposi sarcoma, anal cancer, multicentric Castleman's disease, Epstein Barr Virus-positive lymphoma, plasmablastic lymphoma, or Hodgkin's lymphoma
- HIV infection must be documented by medical record, receipt of antiretroviral therapy with at least two agents, HIV RNA detection (>1000 copies/mL), or confirmed HIV antibody/antigen tests
- Participants with HIV must have a diagnosis of cancer or a condition placing them at higher cancer risk
- Participant or legally authorized representative must be able to provide written informed consent
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years
Participants donate blood and/or tumor tissue samples for research. Samples may be collected from previous procedures or upcoming procedures.
1 visit for blood donation; additional visits if donating tissue samples
Trial Site Locations
Total: 8 locations
1
UC San Diego Moores Cancer Center
La Jolla, California, United States, 92093
Actively Recruiting
2
University of California, San Francisco
San Francisco, California, United States, 94110
Actively Recruiting
3
George Washington University
Washington D.C., District of Columbia, United States, 20052
Actively Recruiting
4
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
5
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States, 21774
Actively Recruiting
6
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
7
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
8
Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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