Actively Recruiting
Analgesic Effect of Combination of Superior Hypogastric Plexus Block and Transversus Abdominis Plane Block in Abdominal Hysterectomies: A Randomized Controlled Trial
Led by Tanta University · Updated on 2026-05-27
44
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to assess the pain relief effect of combining superior hypogastric plexus block with transversus abdominis plane block in women undergoing abdominal hysterectomies. Abdominal hysterectomy is a major surgery often linked to significant postoperative pain, and inadequate pain control can delay recovery and cause complications. A multimodal postoperative pain management approach is recommended for better outcomes. Participants will be randomly assigned to one of two groups. One group will receive a superior hypogastric plexus block and a transversus abdominis plane block using bupivacaine 0.25%. The other group will receive a sham superior hypogastric plexus block using saline combined with a transversus abdominis plane block using bupivacaine 0.25%. Both blocks involve injections of 20ml solutions. This trial uses a double-blind design to compare the analgesic effects of these interventions. Participants will be monitored for 24 hours after surgery to evaluate the time until they first request rescue pain medication, total morphine use, pain intensity, quality of recovery, and any adverse events. Assessments will include pain scoring and recovery quality evaluations during this period. The study aims to provide detailed information on pain control effectiveness and safety following these regional blocks after abdominal hysterectomy.
CONDITIONS
Brief Title
Combination of Superior Hypogastric Plexus Block and Transversus Abdominis Plane Block in Abdominal Hysterectomies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 2 18 years.
- Female participants.
- American Society of Anesthesiology (ASA) physical status I-II.
- Scheduled for abdominal hysterectomy under general anesthesia.
You will not qualify if you...
- Allergies to local anesthetics.
- Body mass index (BMI) over 35 kg/m2.
- Opioid dependency.
- Cognitive impairment.
- Bleeding or clotting disorders.
- Psychiatric or neurological disorders.
- Local infection at injection site.
- Severe heart, lung, liver, or kidney dysfunction.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Perioperative period on the day of surgery
Participants receive either a combination of superior hypogastric plexus block and transverse abdominis plane block or a sham superior hypogastric plexus block with transverse abdominis plane block during abdominal hysterectomy for postoperative pain management.
1 treatment visit (in-person)
Duration - 24 hours postoperatively
Participants are monitored for pain levels, morphine consumption, recovery quality, and adverse events after surgery.
Approximately 1 follow-up visit within 24 hours after surgery
Trial Site Locations
Total: 1 location
1
Tanta University
Tanta, El-Gharbia, Egypt, 31527
Actively Recruiting
Research Team
M
Mohammed S Elsharkawy, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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