Actively Recruiting
Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets
Led by Sharif Medical Research Center · Updated on 2025-05-16
44
Participants Needed
2
Research Sites
17 weeks
Total Duration
On this page
Sponsors
S
Sharif Medical Research Center
Lead Sponsor
U
Universiti Sains Malaysia
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether laser therapy can improve wound healing and bone regeneration after tooth extraction. This clinical trial compares the effects of an active laser treatment versus a sham (inactive) laser to determine if the laser enhances recovery in dental sockets. The goal is to better understand the role of laser therapy in dental healing processes, with careful monitoring over one year. Participants will receive a combination of low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) immediately after tooth extraction. The LLLT uses a 300-micron tip at 0.5 watts in a scanning motion just above the tissue, while the HILT is applied directly to the blood-filled extraction socket at 2 watts in continuous mode. The control group will receive sham laser therapy with the device turned off but otherwise identical treatment. During the study, participants will record their pain levels on days 2, 4, 6, and 14 after extraction. They will visit the clinic for a follow-up at 10 days and again at 4 months for evaluation. Researchers will assess wound healing and bone regeneration over one year. The trial includes safety monitoring and long-term assessment of laser effects on dental socket recovery.
CONDITIONS
Brief Title
Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 21 years old, regardless of gender
- Non-traumatic tooth extraction of the lower jaw is indicated
- Willing for dental implant surgery
- Dental appointments are available at the study place
- Absence of active infection at the extraction site
- Signed informed permission is provided.
You will not qualify if you...
- Pregnant, lactating, and menopausal women
- Smokers
- Those having head and neck radiotherapy
- Those with any acute infection, immune deficiency, or metabolic conditions such as diabetes mellitus and osteoporosis
- Patients with surgical complications such as bleeding or operational difficulties
- Procedures lasting longer than 90 minutes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment session on the day of tooth extraction
Participants receive laser therapy or sham treatment immediately after tooth extraction to support wound healing and bone regeneration of dental sockets.
1 visit (in-person)
Duration - 1 year
Participants are monitored for wound healing, bone regeneration, and pain intensity over one year after treatment.
Periodic visits for assessments during the 1 year follow-up
Trial Site Locations
Total: 2 locations
1
Sharif Medical and Dental College
Lahore, Punjab Province, Pakistan, 54000
Actively Recruiting
2
Sharif Medical and Dental College
Lahore, Pakistan, 54000
Actively Recruiting
Research Team
P
Professor
N
Nauman R Khan, MPhil
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
4
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