Investigation of the Effects of Tranexamic Acid Solution Irrigation on Bleeding, Surgical Field Visibility, and Postoperative Edema in the Extraction of Horizontally Impacted Third Molars

What this Trial Is About

Researchers are evaluating the use of tranexamic acid (TXA) irrigation during the extraction of horizontally impacted third molars to reduce bleeding, improve surgical field visibility, and lessen postoperative swelling (edema). TXA is known as a hemostatic agent that reduces blood loss and the need for transfusions, with minimal significant side effects. The study aims to explore the effect of topical TXA irrigation during tooth extraction under local anesthesia, which has not been previously reported. The study compares two groups in a double-blind, controlled, randomized design. One group will receive saline irrigation during surgery, while the other group will have saline mixed with tranexamic acid as the irrigation solution. The topical application is intended to minimize systemic absorption and reduce risks such as venous thromboembolism. Researchers will monitor intraoperative bleeding, surgical field visibility, and postoperative edema in both groups. Participants will undergo extraction of bone-retained impacted third molars while researchers assess bleeding and visibility during surgery and measure swelling three days after surgery. The study includes patients aged 14 to 40 years who are systemically healthy and free from bleeding disorders. Monitoring will focus on surgical conditions and postoperative recovery, with the main outcome being edema three days after surgery. Total participation spans the surgical procedure and follow-up assessments shortly thereafter.

Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery