Comparing Stem Cell-Derived Exosomes and Platelet-Rich Fibrin for Healing After Tooth Extraction A Randomized Trial Measuring Bone and Tissue Recovery Over 3 Months

What this Trial Is About

Researchers are studying two treatments to help the jawbone heal after a tooth is removed, focusing on people who need a single non-infected tooth extraction in the front or premolar area. The trial compares Platelet-Rich Fibrin PRF, made from the patients own blood, with a newer therapy using exosomes derived from mesenchymal stem cells. These exosomes are tiny particles that may signal the body to repair tissue and grow new bone, potentially improving healing after extraction. The study includes 40 patients randomly divided into two groups. One group receives mesenchymal stem cell-derived exosomes applied to the extraction socket after tooth removal, while the other group receives autologous PRF prepared from their blood and placed in the socket. The main focus is on measuring changes in bone density and ridge dimensions using specialized 3D X-rays CBCT at the time of surgery and three months later. Additional assessments of soft tissue healing, pain, and swelling are done during the first two weeks after surgery. Participants will undergo evaluations including CBCT scans at baseline and three months post-surgery, with soft tissue healing checked at 7 and 14 days after extraction. Patients also report pain levels daily for the first week. The study monitors how well the bone and soft tissue heal, patient comfort, and overall recovery. Participation lasts at least three months, and follow-up visits ensure detailed tracking of healing progress and treatment effects.

Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing