Actively Recruiting
Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing
Led by Al Salam University · Updated on 2026-04-02
40
Participants Needed
1
Research Sites
28 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later. Currently, doctors often use Platelet-Rich Fibrin (PRF), which is made from the patient's own blood, to help the area heal. This research compares PRF to a newer treatment using "exosomes" derived from stem cells. Exosomes are tiny particles that carry signals to tell the body to repair tissue and grow new bone. The goal of this study is to see if these exosomes work better than PRF at keeping the bone strong and thick after an extraction. Researchers will use specialized X-rays (CBCT) to measure the bone three months after the procedure to see which treatment provided better results.
CONDITIONS
Official Title
Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged between 20 and 45 years.
- Require a single non-infected tooth extraction in the aesthetic zone (incisors, canines) or premolar area.
- Presence of adjacent teeth to the extraction site.
- Adequate oral hygiene with Plaque Index less than 20%.
- Willing and able to comply with follow-up visits and 3-month CBCT scan.
- Signed informed consent provided.
You will not qualify if you...
- Have systemic diseases that prevent oral surgery or affect bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism).
- History of head and neck radiation therapy or bisphosphonate use.
- Active infection or acute abscess at the extraction site.
- Heavy smokers (more than 10 cigarettes per day).
- Pregnant or lactating women.
- Poor oral hygiene or active periodontal disease in the rest of the mouth.
- Use medications that affect bone metabolism (e.g., long-term corticosteroids).
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Oral & Maxillofacial Surgery, Al Salam University
Tanta, Gharbia Governorate, Egypt
Actively Recruiting
Research Team
O
Omaima M Sakr, BDS, MSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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