Actively Recruiting
Comparative Study of Combined Microneedling With Either 1% Lactic Acid Solution or Vitamin D3 or Triamcinolone Acetonide in The Treatment of Alopecia Areata
Led by Zagazig University · Updated on 2026-01-26
88
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Alopecia areata (AA) is an autoimmune condition causing non-scarring hair loss in round or oval patches, often affecting the scalp, beard, eyebrows, and eyelashes. This trial studies the effects of combining microneedling with either 1% lactic acid solution, vitamin D3, triamcinolone acetonide, or saline to evaluate hair regrowth in patients with localized patchy AA. The study aims to better understand these treatments' potential in promoting hair growth by modulating immune responses and stimulating hair follicles. Participants will be divided into four groups, each receiving microneedling with a different topical agent: lactic acid 1%, vitamin D3 solution, triamcinolone acetonide injectable suspension, or normal saline. Microneedling sessions will be performed every two weeks for up to six sessions, using a dermapen device with a needle length of 1.5 to 2 mm. Topical anesthetic cream is applied before treatment, and microneedling continues until pinpoint bleeding occurs. During the study, photographs will be taken before, during, and after treatment to monitor progress. The main outcome measured is hair regrowth improvement assessed by the Severity of Alopecia Tool (SALT) score and percentage of hair growth over three months. Participants will be evaluated regularly, with attention to treatment response and safety, under the supervision of study staff until study completion in late 2026.
CONDITIONS
Brief Title
Combined Microneedling With Either 1% Lactic Acid Solution or Vitamin D3 or Triamcinolone Acetonide in The Treatment of Alopecia Areata
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 16 years or older with localized patchy alopecia areata (up to 6 cm in diameter)
- Patients of any sex
- Willing to participate and sign informed consent
You will not qualify if you...
- Received systemic or topical treatment for alopecia areata in the last 3 months
- Have alopecia totalis, universalis, ophiasis, or sisaipho
- Pregnant or lactating females
- Have bleeding or coagulation disorders
- Are immunocompromised
- Known hypersensitivity to vitamin D
- Taking vitamin D supplements in the last 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 weeks
Participants undergo microneedling combined with either 1% lactic acid solution, vitamin D3, triamcinolone acetonide, or normal saline. Sessions are done every 2 weeks for up to six sessions.
Up to 6 visits every 2 weeks (in-person)
Duration - 3 months
Participants are monitored for hair regrowth improvement assessed by SALT score and percentage of hair growth.
Visits as scheduled by the study team
Trial Site Locations
Total: 1 location
1
Rana Ehab
Zagazig, Egypt, 44519
Actively Recruiting
Research Team
R
rana ehab hamed ehab, md
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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