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Comparing Antiplaque Effects of Titania Nanoparticle Fluoride Varnish Versus Conventional Fluoride Varnish in Patients with Fixed Braces
Led by Pakistan Institute of Medical Sciences · Updated on 2025-09-25
20
Participants Needed
1
Research Sites
21 weeks
Total Duration
AI-Summary
What this Trial Is About
This research aims to compare the antiplaque effects of a novel fluoride varnish infused with titania nanoparticles derived from moringa oleifera leaves extract against a conventional fluoride varnish in patients undergoing fixed multibracket orthodontic treatment. The study focuses on dental plaque accumulation and evaluates the potential benefits of nanoparticle-enhanced fluoride varnishes in dental care. Participants are randomly assigned to one of two groups Group A receives the conventional fluoride varnish, while Group B receives the fluoride varnish infused with titania nanoparticles. Both varnishes are applied topically to the teeth of fixed orthodontic patients. The study is designed as a triple-blind randomized controlled trial to ensure unbiased assessment. Over six months, researchers will measure the plaque inhibitory effects using a modified plaque index, along with plaque bacterial load and pH levels. Participants will undergo regular dental assessments to monitor these outcomes. The involvement period includes treatment application and follow-up to evaluate differences in plaque accumulation between the two varnishes.
CONDITIONS
Brief Title
Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.
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