+1 877 705 1914• 24 / 7
HIPAA Compliant
ISO 27001 Certified

Actively Recruiting

Phase Not Applicable
Age: 16Years - 30Years
All Genders
Healthy Volunteers
ID07180849

Comparing Antiplaque Effects of Titania Nanoparticle Fluoride Varnish Versus Conventional Fluoride Varnish in Patients with Fixed Braces

Led by Pakistan Institute of Medical Sciences · Updated on 2025-09-25

20

Participants Needed

1

Research Sites

21 weeks

Total Duration

AI-Summary

What this Trial Is About

This research aims to compare the antiplaque effects of a novel fluoride varnish infused with titania nanoparticles derived from moringa oleifera leaves extract against a conventional fluoride varnish in patients undergoing fixed multibracket orthodontic treatment. The study focuses on dental plaque accumulation and evaluates the potential benefits of nanoparticle-enhanced fluoride varnishes in dental care. Participants are randomly assigned to one of two groups Group A receives the conventional fluoride varnish, while Group B receives the fluoride varnish infused with titania nanoparticles. Both varnishes are applied topically to the teeth of fixed orthodontic patients. The study is designed as a triple-blind randomized controlled trial to ensure unbiased assessment. Over six months, researchers will measure the plaque inhibitory effects using a modified plaque index, along with plaque bacterial load and pH levels. Participants will undergo regular dental assessments to monitor these outcomes. The involvement period includes treatment application and follow-up to evaluate differences in plaque accumulation between the two varnishes.

CONDITIONS

Brief Title

Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here