Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia After Lumbar Spine Surgery

What this Trial Is About

Researchers are evaluating the pain relief effects and safety of three drugs—oliceridine, morphine, and sufentanil—in patients undergoing elective lumbar spine surgery. This randomized controlled trial aims to compare these medications when used for postoperative pain control, focusing on how well they reduce pain during movement six hours after surgery. The study also examines side effects such as nausea, vomiting, sleepiness, breathing problems, and itching within the first 48 hours after surgery. Participants are randomly assigned to one of three groups to receive intravenous patient-controlled analgesia after their surgery. The oliceridine group receives a 1.5 mg loading dose followed by a continuous infusion of 0.01 mg per kilogram per hour. The morphine group receives a 4 mg loading dose followed by an infusion of 0.03 mg per kilogram per hour. The sufentanil group receives a 4 microgram loading dose followed by an infusion of 0.03 micrograms per kilogram per hour. Each infusion is diluted in 100 ml of saline and delivered at a rate of 2 ml per hour. During the study, participants' pain levels are assessed using a Visual Analogue Scale both at rest and during movement at multiple time points up to 48 hours after surgery. Researchers also monitor sedation levels, the number of times patients use the pain control button, the need for extra pain medication, and vital signs shortly after the initial dose. The study lasts through the first 48 hours after surgery, focusing on both pain relief and safety outcomes to better understand how these medications compare.

Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial