Comparison of High Flow Nasal Oxygen and Standard Nasal Oxygen Therapy in Preventing Hypoxia in Minor and Moderate Burn Patients Under Sedation

What this Trial Is About

Researchers are evaluating oxygen therapies in adult burn patients undergoing surgery under deep sedation to prevent low oxygen levels (hypoxemia). This observational prospective case-control study compares the effects of standard nasal oxygen therapy and High Flow Nasal Oxygen (HFNO) therapy in patients with minor to moderate burns. The study includes volunteers over 18 years old, classified within ASA risk groups I-III, treated at a burns center in Ankara Bilkent City Hospital. The study involves two groups: one receiving standard nasal oxygen therapy and the other receiving HFNO. Patients in the standard group are preoxygenated with 100% oxygen at 8 liters per minute for 3 minutes, then receive 3 liters per minute during the procedure. The HFNO group is preoxygenated with 100% oxygen at 40 liters per minute for 3 minutes and receives HFNO at 50 liters per minute with 50% oxygen throughout the procedure. Sedation includes medications such as midazolam, fentanyl, and propofol-ketamine, with doses adjusted based on sedation monitoring. Participants will be monitored continuously for oxygen saturation, heart rate, blood pressure, and sedation levels before and every 5 minutes during the procedure. Researchers will record anesthetic doses, procedure duration, and any interventions needed to manage apnea or desaturation. Sedation quality and recovery scores will also be evaluated. The main outcome is oxygen saturation levels, with secondary outcomes including the number of interventions performed during sedation. Data will be statistically analyzed to compare the two oxygen therapies.

Comparison of High Flow Nasal Oxygen and Nasal Cannula in Burn Patients Under Sedation