Comparison of High Flow Nasal Oxygen and Standard Nasal Oxygen Therapy in Preventing Low Oxygen Levels in Minor and Moderate Burn Patients Under Sedation

What this Trial Is About

This research evaluates oxygen therapies for patients with minor and moderate burns undergoing surgery under deep sedation. The study compares the effects of standard nasal oxygen therapy and High Flow Nasal Oxygen (HFNO) therapy in preventing low oxygen levels (hypoxemia) during sedation. Burn-related pain often requires high doses of opioids and sedatives, which can cause breathing problems, making oxygen support important during procedures. The study includes 70 patients divided into two groups: one receiving standard nasal oxygen at a flow rate of 8 liters per minute and the other receiving HFNO at 40 liters per minute, both with 100% oxygen during a 3-minute preoxygenation before sedation. Sedation is induced with midazolam, fentanyl, and propofol-ketamine, with doses adjusted based on patient monitoring. During the procedure, heart rate, blood pressure, oxygen saturation, and sedation levels are continuously recorded every 5 minutes. Participants will be closely monitored for oxygen saturation levels before induction and throughout surgery to assess the effectiveness of each oxygen therapy. Other clinical parameters, sedation scales, and recovery scores will also be measured. If breathing difficulties occur, interventions such as patient stimulation or increased oxygen flow will be applied. Data analysis will explore differences between groups with statistical methods to evaluate the therapies' impacts on preventing hypoxia during sedation.

Comparison of High Flow Nasal Oxygen and Nasal Cannula in Burn Patients Under Sedation