Actively Recruiting
Cardiovascular Responses in Burn Survivors During Exercise
Led by University of Texas Southwestern Medical Center · Updated on 2025-07-18
36
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how different cooling methods affect body temperature and heart stress during exercise in people who have healed from severe burns covering 20% or more of their body. This study includes both burn survivors and non-burned individuals to compare responses in heated conditions. It aims to find ways to reduce heat buildup and cardiovascular stress, which may help burn survivors safely engage in physical activities important for heart and metabolic health. Participants will exercise for 60 minutes in a hot environment under two conditions: no cooling and skin wetting by water spray. Both non-burned individuals and burn survivors with significant burn injuries will complete these exercise sessions to assess how skin wetting influences their ability to cool down and manage cardiovascular load. The study uses a randomized crossover design, meaning each participant experiences both conditions. During the study, core and skin temperatures, heart rate, and blood pressure will be regularly measured before and after exercise. These assessments will help determine how well each cooling method controls body heat and cardiovascular responses. The trial runs from January 2025 to January 2027, with participants aged 18 to 65 years involved. The findings may guide strategies to improve physical activity tolerance for burn survivors.
CONDITIONS
Brief Title
Cardiovascular Responses in Burn Survivors During Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy males and females aged 18 to 65 years
- Free of any underlying medical conditions
- For burn survivors: burn injury covering 20% or more of body surface area with at least 50% full thickness burns requiring skin grafting
- For burn survivors: hospitalization for at least 15 days due to burn injury
You will not qualify if you...
- Any burn-related injuries resulting in at least one night of hospitalization (for non-burned group)
- Heart disease or other chronic medical conditions requiring regular treatment, including cancer, diabetes, and hypertension
- Abnormalities detected on routine screening
- Participation in structured aerobic exercise training programs at moderate to high intensities
- Current smokers or those who smoked regularly within the past 3 years
- Body mass index over 30 kg/m2
- Pregnant individuals
- Extensive unhealed injured skin (for burn survivors)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Two exercise sessions lasting 60 minutes each, timing depends on scheduling
Participants exercise for 60 minutes in the heat under two conditions: with no cooling modality and with skin wetting applied by water spray during exercise. These sessions are used to study cardiovascular and temperature responses.
2 exercise sessions (in-person)
Trial Site Locations
Total: 1 location
1
Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
E
Erin M Harper, B.S.
C
Craig G Crandall, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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